6Q0R
Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005634 | cellular_component | nucleus |
| B | 0016567 | biological_process | protein ubiquitination |
| C | 0016567 | biological_process | protein ubiquitination |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0006397 | biological_process | mRNA processing |
| E | 0000209 | biological_process | protein polyubiquitination |
| E | 0005515 | molecular_function | protein binding |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0016567 | biological_process | protein ubiquitination |
| E | 0032434 | biological_process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| E | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| E | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue OXM B 301 |
| Chain | Residue |
| B | TYR222 |
| B | THR230 |
| B | GLN236 |
| B | LEU244 |
| B | LEU245 |
| B | ASN246 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue O6M B 302 |
| Chain | Residue |
| B | PRO233 |
| B | ALA234 |
| B | PHE235 |
| C | VAL477 |
| C | ARG552 |
| C | VAL556 |
| D | ASN260 |
| D | THR262 |
| D | ASP264 |
| D | MET265 |
| D | HOH401 |
| B | THR230 |
| B | PHE231 |
| B | GLN232 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 303 |
| Chain | Residue |
| B | CYS193 |
| B | CYS196 |
| B | CYS211 |
| B | HIS214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 343 |
| Details | Region: {"description":"WD repeat beta-propeller A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31686031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31693911","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31686031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31693911","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31819272","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31686031","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31693911","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31819272","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PAI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q0W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 78 |
| Details | Domain: {"description":"RRM 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
