6Q0R
Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005634 | cellular_component | nucleus |
| B | 0016567 | biological_process | protein ubiquitination |
| C | 0016567 | biological_process | protein ubiquitination |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0006397 | biological_process | mRNA processing |
| E | 0000209 | biological_process | protein polyubiquitination |
| E | 0005515 | molecular_function | protein binding |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0016567 | biological_process | protein ubiquitination |
| E | 0032434 | biological_process | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| E | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| E | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue OXM B 301 |
| Chain | Residue |
| B | TYR222 |
| B | THR230 |
| B | GLN236 |
| B | LEU244 |
| B | LEU245 |
| B | ASN246 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue O6M B 302 |
| Chain | Residue |
| B | PRO233 |
| B | ALA234 |
| B | PHE235 |
| C | VAL477 |
| C | ARG552 |
| C | VAL556 |
| D | ASN260 |
| D | THR262 |
| D | ASP264 |
| D | MET265 |
| D | HOH401 |
| B | THR230 |
| B | PHE231 |
| B | GLN232 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 303 |
| Chain | Residue |
| B | CYS193 |
| B | CYS196 |
| B | CYS211 |
| B | HIS214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| E | ALA2 | |
| B | CYS196 | |
| B | CYS211 | |
| B | HIS214 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER33 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER95 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER50 |
