6PYH
Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, D) | Insulin-like growth factor 1 receptor | polymer | 1273 | 145279.9 | 2 | UniProt (Q60751) Pfam (PF01030) Pfam (PF00757) Pfam (PF07714) | Mus musculus (Mouse) | Insulin-like growth factor I receptor,IGF-I receptor |
| 2 | B (B) | Insulin-like growth factor I | polymer | 70 | 7663.8 | 1 | UniProt (P05019) Pfam (PF00049) | Homo sapiens (Human) | IGF-I,Mechano growth factor,MGF,Somatomedin-C |
Sequence modifications
A, D: 1 - 1262 (UniProt: Q60751)
| PDB | External Database | Details |
|---|---|---|
| Ala 951 | Tyr 981 | conflict |
| Asn 1107 | Asp 1137 | conflict |
| Gly 1263 | - | expression tag |
| Thr 1264 | - | expression tag |
| Ser 1265 | - | expression tag |
| Ser 1266 | - | expression tag |
| Gly 1267 | - | expression tag |
| Leu 1268 | - | expression tag |
| Glu 1269 | - | expression tag |
| Val 1270 | - | expression tag |
| Leu 1271 | - | expression tag |
| Phe 1272 | - | expression tag |
| Gln 1273 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 298223.6 | |
| All* | Total formula weight | 298223.6 |
