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6PYH

Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
A0005009molecular_functioninsulin receptor activity
A0005010molecular_functioninsulin-like growth factor receptor activity
A0005198molecular_functionstructural molecule activity
A0005515molecular_functionprotein binding
A0005520molecular_functioninsulin-like growth factor binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0005899cellular_componentinsulin receptor complex
A0006468biological_processprotein phosphorylation
A0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
A0007420biological_processbrain development
A0008286biological_processinsulin receptor signaling pathway
A0008544biological_processepidermis development
A0009887biological_processanimal organ morphogenesis
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0030238biological_processmale sex determination
A0030315cellular_componentT-tubule
A0030325biological_processadrenal gland development
A0030424cellular_componentaxon
A0030879biological_processmammary gland development
A0031017biological_processexocrine pancreas development
A0032869biological_processcellular response to insulin stimulus
A0043235cellular_componentreceptor complex
A0043409biological_processnegative regulation of MAPK cascade
A0043410biological_processpositive regulation of MAPK cascade
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0043548molecular_functionphosphatidylinositol 3-kinase binding
A0043560molecular_functioninsulin receptor substrate binding
A0045840biological_processpositive regulation of mitotic nuclear division
A0045893biological_processpositive regulation of DNA-templated transcription
A0046328biological_processregulation of JNK cascade
A0046777biological_processprotein autophosphorylation
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048639biological_processpositive regulation of developmental growth
A0051446biological_processpositive regulation of meiotic cell cycle
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060740biological_processprostate gland epithelium morphogenesis
A0071333biological_processcellular response to glucose stimulus
A0090068biological_processpositive regulation of cell cycle process
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0140014biological_processmitotic nuclear division
B0005179molecular_functionhormone activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0008083molecular_functiongrowth factor activity
D0000165biological_processMAPK cascade
D0000166molecular_functionnucleotide binding
D0004672molecular_functionprotein kinase activity
D0004713molecular_functionprotein tyrosine kinase activity
D0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
D0005009molecular_functioninsulin receptor activity
D0005010molecular_functioninsulin-like growth factor receptor activity
D0005198molecular_functionstructural molecule activity
D0005515molecular_functionprotein binding
D0005520molecular_functioninsulin-like growth factor binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0005899cellular_componentinsulin receptor complex
D0006468biological_processprotein phosphorylation
D0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
D0007420biological_processbrain development
D0008286biological_processinsulin receptor signaling pathway
D0008544biological_processepidermis development
D0009887biological_processanimal organ morphogenesis
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016740molecular_functiontransferase activity
D0030238biological_processmale sex determination
D0030315cellular_componentT-tubule
D0030325biological_processadrenal gland development
D0030424cellular_componentaxon
D0030879biological_processmammary gland development
D0031017biological_processexocrine pancreas development
D0032869biological_processcellular response to insulin stimulus
D0043235cellular_componentreceptor complex
D0043409biological_processnegative regulation of MAPK cascade
D0043410biological_processpositive regulation of MAPK cascade
D0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0043560molecular_functioninsulin receptor substrate binding
D0045840biological_processpositive regulation of mitotic nuclear division
D0045893biological_processpositive regulation of DNA-templated transcription
D0046328biological_processregulation of JNK cascade
D0046777biological_processprotein autophosphorylation
D0048009biological_processinsulin-like growth factor receptor signaling pathway
D0048639biological_processpositive regulation of developmental growth
D0051446biological_processpositive regulation of meiotic cell cycle
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0060740biological_processprostate gland epithelium morphogenesis
D0071333biological_processcellular response to glucose stimulus
D0090068biological_processpositive regulation of cell cycle process
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D0120162biological_processpositive regulation of cold-induced thermogenesis
D0140014biological_processmitotic nuclear division
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues29
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK
ChainResidueDetails
ALEU976-LYS1004

site_idPS00239
Number of Residues9
DetailsRECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR
ChainResidueDetails
AASP1131-ARG1139

site_idPS00262
Number of Residues15
DetailsINSULIN Insulin family signature. CCFRsCDlrrLemyC
ChainResidueDetails
BCYS47-CYS61

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues388
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AASP712-HIS906
DASP712-HIS906

site_idSWS_FT_FI2
Number of Residues46
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU907-HIS930
DLEU907-HIS930

site_idSWS_FT_FI3
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASN1107
DASN1107

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU976
ALYS1004
DLEU976
DLYS1004

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P08069
ChainResidueDetails
AALA951
DALA951

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:P08069
ChainResidueDetails
ATYR1133
ATYR1137
ATYR1138
DTYR1133
DTYR1137
DTYR1138

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine; by GSK3-beta => ECO:0000269|PubMed:22685298
ChainResidueDetails
ASER1250
DSER1250

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:22685298
ChainResidueDetails
ASER1254
DSER1254

site_idSWS_FT_FI9
Number of Residues22
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN21
AASN593
AASN884
DASN21
DASN72
DASN105
DASN215
DASN284
DASN388
DASN409
DASN505
AASN72
DASN578
DASN593
DASN884
AASN105
AASN215
AASN284
AASN388
AASN409
AASN505
AASN578

site_idSWS_FT_FI10
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973
ChainResidueDetails
AASN611
AASN727
AASN735
DASN611
DASN727
DASN735

site_idSWS_FT_FI11
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19656770
ChainResidueDetails
AASN718
AASN871
DASN718
DASN871

site_idSWS_FT_FI12
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P08069
ChainResidueDetails
ALYS1140
ALYS1143
DLYS1140
DLYS1143

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PDB entries from 2025-06-18

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