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6PYH

Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001965molecular_functionG-protein alpha-subunit binding
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
A0005009molecular_functioninsulin receptor activity
A0005010molecular_functioninsulin-like growth factor receptor activity
A0005158molecular_functioninsulin receptor binding
A0005198molecular_functionstructural molecule activity
A0005515molecular_functionprotein binding
A0005520molecular_functioninsulin-like growth factor binding
A0005524molecular_functionATP binding
A0005730cellular_componentnucleolus
A0005886cellular_componentplasma membrane
A0005899cellular_componentinsulin receptor complex
A0005901cellular_componentcaveola
A0005929cellular_componentcilium
A0006468biological_processprotein phosphorylation
A0006955biological_processimmune response
A0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
A0007409biological_processaxonogenesis
A0007420biological_processbrain development
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0008544biological_processepidermis development
A0009887biological_processanimal organ morphogenesis
A0010656biological_processnegative regulation of muscle cell apoptotic process
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0021549biological_processcerebellum development
A0030010biological_processestablishment of cell polarity
A0030238biological_processmale sex determination
A0030315cellular_componentT-tubule
A0030325biological_processadrenal gland development
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030879biological_processmammary gland development
A0031017biological_processexocrine pancreas development
A0031175biological_processneuron projection development
A0031994molecular_functioninsulin-like growth factor I binding
A0032467biological_processpositive regulation of cytokinesis
A0032869biological_processcellular response to insulin stimulus
A0033690biological_processpositive regulation of osteoblast proliferation
A0035867cellular_componentalphav-beta3 integrin-IGF-1-IGF1R complex
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043235cellular_componentreceptor complex
A0043243biological_processpositive regulation of protein-containing complex disassembly
A0043409biological_processnegative regulation of MAPK cascade
A0043410biological_processpositive regulation of MAPK cascade
A0043548molecular_functionphosphatidylinositol 3-kinase binding
A0043559molecular_functioninsulin binding
A0043560molecular_functioninsulin receptor substrate binding
A0044849biological_processestrous cycle
A0044877molecular_functionprotein-containing complex binding
A0045056biological_processtranscytosis
A0045471biological_processresponse to ethanol
A0045840biological_processpositive regulation of mitotic nuclear division
A0045893biological_processpositive regulation of DNA-templated transcription
A0046328biological_processregulation of JNK cascade
A0046777biological_processprotein autophosphorylation
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048639biological_processpositive regulation of developmental growth
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0048680biological_processpositive regulation of axon regeneration
A0051054biological_processpositive regulation of DNA metabolic process
A0051446biological_processpositive regulation of meiotic cell cycle
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060740biological_processprostate gland epithelium morphogenesis
A0071333biological_processcellular response to glucose stimulus
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0090031biological_processpositive regulation of steroid hormone biosynthetic process
A0090068biological_processpositive regulation of cell cycle process
A0097062biological_processdendritic spine maintenance
A0097242biological_processamyloid-beta clearance
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0140318molecular_functionprotein transporter activity
A1902065biological_processresponse to L-glutamate
A1902911cellular_componentprotein kinase complex
A1903944biological_processnegative regulation of hepatocyte apoptotic process
A1904193biological_processnegative regulation of cholangiocyte apoptotic process
A1904646biological_processcellular response to amyloid-beta
A1990314biological_processcellular response to insulin-like growth factor stimulus
B0005179molecular_functionhormone activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0008083molecular_functiongrowth factor activity
D0000166molecular_functionnucleotide binding
D0001965molecular_functionG-protein alpha-subunit binding
D0004672molecular_functionprotein kinase activity
D0004713molecular_functionprotein tyrosine kinase activity
D0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
D0005009molecular_functioninsulin receptor activity
D0005010molecular_functioninsulin-like growth factor receptor activity
D0005158molecular_functioninsulin receptor binding
D0005198molecular_functionstructural molecule activity
D0005515molecular_functionprotein binding
D0005520molecular_functioninsulin-like growth factor binding
D0005524molecular_functionATP binding
D0005730cellular_componentnucleolus
D0005886cellular_componentplasma membrane
D0005899cellular_componentinsulin receptor complex
D0005901cellular_componentcaveola
D0005929cellular_componentcilium
D0006468biological_processprotein phosphorylation
D0006955biological_processimmune response
D0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
D0007409biological_processaxonogenesis
D0007420biological_processbrain development
D0008284biological_processpositive regulation of cell population proliferation
D0008286biological_processinsulin receptor signaling pathway
D0008544biological_processepidermis development
D0009887biological_processanimal organ morphogenesis
D0010656biological_processnegative regulation of muscle cell apoptotic process
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016740molecular_functiontransferase activity
D0021549biological_processcerebellum development
D0030010biological_processestablishment of cell polarity
D0030238biological_processmale sex determination
D0030315cellular_componentT-tubule
D0030325biological_processadrenal gland development
D0030335biological_processpositive regulation of cell migration
D0030424cellular_componentaxon
D0030879biological_processmammary gland development
D0031017biological_processexocrine pancreas development
D0031175biological_processneuron projection development
D0031994molecular_functioninsulin-like growth factor I binding
D0032467biological_processpositive regulation of cytokinesis
D0032869biological_processcellular response to insulin stimulus
D0033690biological_processpositive regulation of osteoblast proliferation
D0035867cellular_componentalphav-beta3 integrin-IGF-1-IGF1R complex
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043066biological_processnegative regulation of apoptotic process
D0043235cellular_componentreceptor complex
D0043243biological_processpositive regulation of protein-containing complex disassembly
D0043409biological_processnegative regulation of MAPK cascade
D0043410biological_processpositive regulation of MAPK cascade
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0043559molecular_functioninsulin binding
D0043560molecular_functioninsulin receptor substrate binding
D0044849biological_processestrous cycle
D0044877molecular_functionprotein-containing complex binding
D0045056biological_processtranscytosis
D0045471biological_processresponse to ethanol
D0045840biological_processpositive regulation of mitotic nuclear division
D0045893biological_processpositive regulation of DNA-templated transcription
D0046328biological_processregulation of JNK cascade
D0046777biological_processprotein autophosphorylation
D0048009biological_processinsulin-like growth factor receptor signaling pathway
D0048639biological_processpositive regulation of developmental growth
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0048680biological_processpositive regulation of axon regeneration
D0051054biological_processpositive regulation of DNA metabolic process
D0051446biological_processpositive regulation of meiotic cell cycle
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0060740biological_processprostate gland epithelium morphogenesis
D0071333biological_processcellular response to glucose stimulus
D0071560biological_processcellular response to transforming growth factor beta stimulus
D0090031biological_processpositive regulation of steroid hormone biosynthetic process
D0090068biological_processpositive regulation of cell cycle process
D0097062biological_processdendritic spine maintenance
D0097242biological_processamyloid-beta clearance
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D0120162biological_processpositive regulation of cold-induced thermogenesis
D0140318molecular_functionprotein transporter activity
D1902065biological_processresponse to L-glutamate
D1902911cellular_componentprotein kinase complex
D1903944biological_processnegative regulation of hepatocyte apoptotic process
D1904193biological_processnegative regulation of cholangiocyte apoptotic process
D1904646biological_processcellular response to amyloid-beta
D1990314biological_processcellular response to insulin-like growth factor stimulus
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues29
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK
ChainResidueDetails
ALEU976-LYS1004

site_idPS00239
Number of Residues9
DetailsRECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR
ChainResidueDetails
AASP1131-ARG1139

site_idPS00262
Number of Residues15
DetailsINSULIN Insulin family signature. CCFRsCDlrrLemyC
ChainResidueDetails
BCYS47-CYS61

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues120
DetailsDomain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues22
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19656770","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues20
DetailsRegion: {"description":"A"}
ChainResidueDetails

242500

PDB entries from 2025-10-01

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