6PT1

Crystal Structure of Class D Beta-lactamase OXA-48 with Meropenem

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Class D Carbapenemase OXA-48	polymer	263	30826.9	4	UniProt (A0A482LRD5) Pfam (PF00905) UniProt (by SIFTS) (Q6XEC0)	Klebsiella pneumoniae
2	E, F, H, J, K... (A, B, C, D)	CHLORIDE ION	non-polymer		35.5	6	Chemie (CL)
3	G, I, L, O (A, B, C, D)	(4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid	non-polymer		385.5	4	Chemie (MER)
4	M, P (C, D)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	544	Chemie (HOH)

Sequence modifications

A, B, C, D: 25 - 265 (UniProt: A0A482LRD5)

PDB	External Database	Details
Met 3	-	initiating methionine
Lys 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Met 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
Glu 18	-	expression tag
Asn 19	-	expression tag
Leu 20	-	expression tag
Tyr 21	-	expression tag
Phe 22	-	expression tag
Gln 23	-	expression tag
Gly 24	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	123307.5
Non-Polymers*	Number of molecules	12
	Total formula weight	1938.8
All*	Total formula weight	125246.3

*Water molecules are not included.