6PJJ
Human PRPF4B bound to benzothiophene inhibitor 224
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Serine/threonine-protein kinase PRP4 homolog | polymer | 351 | 40963.4 | 4 | UniProt (Q13523) Pfam (PF00069) | Homo sapiens (Human) | PRP4 kinase,PRP4 pre-mRNA-processing factor 4 homolog |
| 2 | E, J, P, T (A, B, C, D) | 4-(5-{[(3-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide | non-polymer | 407.5 | 4 | Chemie (OCJ) | |||
| 3 | F, L, M, N, S... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 4 | G, H, I, K, O... (A, B, C, D) | PHOSPHATE ION | non-polymer | 95.0 | 8 | Chemie (PO4) | |||
| 5 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 226 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 657 - 1005 (UniProt: Q13523)
| PDB | External Database | Details |
|---|---|---|
| Ser 655 | - | expression tag |
| Met 656 | - | expression tag |
| Leu 754 | Phe 754 | conflict |
| Phe 851 | Val 851 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 163853.5 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2886.3 | |
| All* | Total formula weight | 166739.8 |
