6PJJ
Human PRPF4B bound to benzothiophene inhibitor 224
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004674 | molecular_function | protein serine/threonine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004674 | molecular_function | protein serine/threonine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
| D | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue OCJ A 1101 |
| Chain | Residue |
| A | THR693 |
| A | ASP834 |
| A | HOH1207 |
| A | ALA715 |
| A | LYS717 |
| A | GLU732 |
| A | LEU751 |
| A | PHE767 |
| A | ASN773 |
| A | GLU776 |
| A | LEU822 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 1102 |
| Chain | Residue |
| A | LEU739 |
| A | ASN740 |
| A | ASP743 |
| A | ASP746 |
| A | HIS749 |
| A | CYS750 |
| A | ARG752 |
| A | LEU805 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 1103 |
| Chain | Residue |
| A | ARG686 |
| A | ARG709 |
| A | ARG755 |
| A | PO41104 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 1104 |
| Chain | Residue |
| A | ARG755 |
| A | PO41103 |
| B | ARG703 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 1105 |
| Chain | Residue |
| A | PTR849 |
| A | ARG853 |
| A | ARG856 |
| A | HOH1240 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residue OCJ B 1101 |
| Chain | Residue |
| B | THR693 |
| B | GLY694 |
| B | ALA715 |
| B | LYS717 |
| B | LEU751 |
| B | PHE767 |
| B | LEU770 |
| B | SER771 |
| B | ASN773 |
| B | GLU776 |
| B | LEU822 |
| B | ASP834 |
| B | HOH1236 |
| D | SER947 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 1102 |
| Chain | Residue |
| B | PTR849 |
| B | ARG853 |
| B | ARG856 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1103 |
| Chain | Residue |
| B | ALA791 |
| B | SER794 |
| B | LYS827 |
| B | THR828 |
| C | ASP741 |
| C | ALA742 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1104 |
| Chain | Residue |
| B | TYR795 |
| B | LYS827 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1105 |
| Chain | Residue |
| B | LEU904 |
| B | LYS905 |
| B | LYS977 |
| B | ASP981 |
| B | HOH1211 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 1106 |
| Chain | Residue |
| B | ARG686 |
| B | ARG755 |
| B | HOH1210 |
| C | LYS971 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue OCJ C 1101 |
| Chain | Residue |
| C | THR693 |
| C | GLY694 |
| C | ALA715 |
| C | LYS717 |
| C | LEU751 |
| C | PHE767 |
| C | LEU770 |
| C | ASN773 |
| C | GLU776 |
| C | LEU822 |
| C | ASP834 |
| C | HOH1216 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 C 1102 |
| Chain | Residue |
| B | LYS971 |
| C | ARG686 |
| C | ARG755 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 C 1103 |
| Chain | Residue |
| C | PTR849 |
| C | ARG853 |
| C | ARG856 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 1104 |
| Chain | Residue |
| C | LYS905 |
| C | LYS977 |
| C | ASP981 |
| C | HOH1233 |
| site_id | AD7 |
| Number of Residues | 11 |
| Details | binding site for residue OCJ D 1101 |
| Chain | Residue |
| C | SER947 |
| D | THR693 |
| D | GLY694 |
| D | ALA715 |
| D | LYS717 |
| D | LEU751 |
| D | ASN773 |
| D | GLU776 |
| D | LEU822 |
| D | ASP834 |
| D | HOH1201 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue EDO D 1102 |
| Chain | Residue |
| D | ASP743 |
| D | ASP746 |
| D | PHE748 |
| D | HIS749 |
| D | CYS750 |
| D | ARG752 |
| D | LEU805 |
| D | LEU739 |
| D | ASN740 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 1103 |
| Chain | Residue |
| C | MET930 |
| C | ILE932 |
| C | GLU941 |
| D | ARG853 |
| D | PRO890 |
| D | LYS892 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 D 1104 |
| Chain | Residue |
| D | ARG686 |
| D | ARG709 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 1105 |
| Chain | Residue |
| D | PTR849 |
| D | ARG853 |
| D | ARG856 |
| D | HOH1202 |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHaDIKpdNILV |
| Chain | Residue | Details |
| A | ILE811-VAL823 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP815 | |
| B | ASP815 | |
| C | ASP815 | |
| D | ASP815 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | THR693 | |
| A | LYS717 | |
| B | THR693 | |
| B | LYS717 | |
| C | THR693 | |
| C | LYS717 | |
| D | THR693 | |
| D | LYS717 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS717 | |
| B | LYS717 | |
| C | LYS717 | |
| D | LYS717 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | PTR849 | |
| B | PTR849 | |
| C | PTR849 | |
| D | PTR849 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5RKH1 |
| Chain | Residue | Details |
| A | SER852 | |
| B | SER852 | |
| C | SER852 | |
| D | SER852 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS659 | |
| B | LYS659 | |
| C | LYS659 | |
| D | LYS659 |
