6PJJ

Human PRPF4B bound to benzothiophene inhibitor 224

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0045292	biological_process	mRNA cis splicing, via spliceosome
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0045292	biological_process	mRNA cis splicing, via spliceosome
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
C	0045292	biological_process	mRNA cis splicing, via spliceosome
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
D	0045292	biological_process	mRNA cis splicing, via spliceosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue OCJ A 1101

Chain	Residue
A	THR693
A	ASP834
A	HOH1207
A	ALA715
A	LYS717
A	GLU732
A	LEU751
A	PHE767
A	ASN773
A	GLU776
A	LEU822

---

site_id	AC2
Number of Residues	8
Details	binding site for residue EDO A 1102

Chain	Residue
A	LEU739
A	ASN740
A	ASP743
A	ASP746
A	HIS749
A	CYS750
A	ARG752
A	LEU805

---

site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 A 1103

Chain	Residue
A	ARG686
A	ARG709
A	ARG755
A	PO41104

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PO4 A 1104

Chain	Residue
A	ARG755
A	PO41103
B	ARG703

---

site_id	AC5
Number of Residues	4
Details	binding site for residue PO4 A 1105

Chain	Residue
A	PTR849
A	ARG853
A	ARG856
A	HOH1240

---

site_id	AC6
Number of Residues	14
Details	binding site for residue OCJ B 1101

Chain	Residue
B	THR693
B	GLY694
B	ALA715
B	LYS717
B	LEU751
B	PHE767
B	LEU770
B	SER771
B	ASN773
B	GLU776
B	LEU822
B	ASP834
B	HOH1236
D	SER947

---

site_id	AC7
Number of Residues	3
Details	binding site for residue PO4 B 1102

Chain	Residue
B	PTR849
B	ARG853
B	ARG856

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO B 1103

Chain	Residue
B	ALA791
B	SER794
B	LYS827
B	THR828
C	ASP741
C	ALA742

---

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO B 1104

Chain	Residue
B	TYR795
B	LYS827

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO B 1105

Chain	Residue
B	LEU904
B	LYS905
B	LYS977
B	ASP981
B	HOH1211

---

site_id	AD2
Number of Residues	4
Details	binding site for residue PO4 B 1106

Chain	Residue
B	ARG686
B	ARG755
B	HOH1210
C	LYS971

---

site_id	AD3
Number of Residues	12
Details	binding site for residue OCJ C 1101

Chain	Residue
C	THR693
C	GLY694
C	ALA715
C	LYS717
C	LEU751
C	PHE767
C	LEU770
C	ASN773
C	GLU776
C	LEU822
C	ASP834
C	HOH1216

---

site_id	AD4
Number of Residues	3
Details	binding site for residue PO4 C 1102

Chain	Residue
B	LYS971
C	ARG686
C	ARG755

---

site_id	AD5
Number of Residues	3
Details	binding site for residue PO4 C 1103

Chain	Residue
C	PTR849
C	ARG853
C	ARG856

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO C 1104

Chain	Residue
C	LYS905
C	LYS977
C	ASP981
C	HOH1233

---

site_id	AD7
Number of Residues	11
Details	binding site for residue OCJ D 1101

Chain	Residue
C	SER947
D	THR693
D	GLY694
D	ALA715
D	LYS717
D	LEU751
D	ASN773
D	GLU776
D	LEU822
D	ASP834
D	HOH1201

---

site_id	AD8
Number of Residues	9
Details	binding site for residue EDO D 1102

Chain	Residue
D	ASP743
D	ASP746
D	PHE748
D	HIS749
D	CYS750
D	ARG752
D	LEU805
D	LEU739
D	ASN740

---

site_id	AD9
Number of Residues	6
Details	binding site for residue EDO D 1103

Chain	Residue
C	MET930
C	ILE932
C	GLU941
D	ARG853
D	PRO890
D	LYS892

---

site_id	AE1
Number of Residues	2
Details	binding site for residue PO4 D 1104

Chain	Residue
D	ARG686
D	ARG709

---

site_id	AE2
Number of Residues	4
Details	binding site for residue EDO D 1105

Chain	Residue
D	PTR849
D	ARG853
D	ARG856
D	HOH1202

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHaDIKpdNILV

Chain	Residue	Details
A	ILE811-VAL823

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RKH1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---