6PIT

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with SRC2 Stapled Peptide 41A and Estradiol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Estrogen receptor	polymer	262	29949.3	1	UniProt (P03372) Pfam (PF00104) In PDB	Homo sapiens (Human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	B	Estrogen receptor	polymer	262	29949.3	1	UniProt (P03372) Pfam (PF00104) In PDB	Homo sapiens (Human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
3	D, C	Stapled Peptide 41A	polymer	12	1586.8	2		synthetic construct
4	A, B	ESTRADIOL	non-polymer		272.4	2	Chemie (EST)
5		water	water		18.0	152	Chemie (HOH)

Sequence modifications

A: 297 - 554 (UniProt: P03372)

PDB	External Database	Details
Glu 293	-	expression tag
Met 294	-	expression tag
Asp 295	-	expression tag
Pro 296	-	expression tag
Ser 537	Tyr 537	engineered mutation

B: 297 - 554 (UniProt: P03372)

PDB	External Database	Details
Glu 293	-	expression tag
Met 294	-	expression tag
Asp 295	-	expression tag
Pro 296	-	expression tag
Ser 537	Tyr 537	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	63072.2
Non-Polymers*	Number of molecules	2
	Total formula weight	544.8
All*	Total formula weight	63617.0

*Water molecules are not included.