6PIT
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with SRC2 Stapled Peptide 41A and Estradiol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Estrogen receptor | polymer | 262 | 29949.3 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | B | Estrogen receptor | polymer | 262 | 29949.3 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
3 | D, C | Stapled Peptide 41A | polymer | 12 | 1586.8 | 2 | synthetic construct | ||
4 | A, B | ESTRADIOL | non-polymer | 272.4 | 2 | Chemie (EST) | |||
5 | water | water | 18.0 | 152 | Chemie (HOH) |
Sequence modifications
A: 297 - 554 (UniProt: P03372)
B: 297 - 554 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Glu 293 | - | expression tag |
Met 294 | - | expression tag |
Asp 295 | - | expression tag |
Pro 296 | - | expression tag |
Ser 537 | Tyr 537 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Glu 293 | - | expression tag |
Met 294 | - | expression tag |
Asp 295 | - | expression tag |
Pro 296 | - | expression tag |
Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 63072.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 544.8 | |
All* | Total formula weight | 63617.0 |