6PIT
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with SRC2 Stapled Peptide 41A and Estradiol
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue EST A 601 |
| Chain | Residue |
| A | LEU346 |
| A | GLU353 |
| A | LEU387 |
| A | ARG394 |
| A | MET421 |
| A | GLY521 |
| A | HIS524 |
| A | LEU525 |
| A | HOH736 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EST B 601 |
| Chain | Residue |
| B | MET343 |
| B | LEU346 |
| B | GLU353 |
| B | LEU387 |
| B | ARG394 |
| B | MET421 |
| B | HIS524 |
| B | LEU525 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for Di-peptide ARG E 7 and LOU E 8 |
| Chain | Residue |
| C | LEU9 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide LOU E 8 and LEU E 9 |
| Chain | Residue |
| A | GLN375 |
| A | VAL376 |
| C | ARG7 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| B | GLU353 | |
| B | ARG394 | |
| B | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| B | SER537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| B | CYS447 |
