6P67
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, H (A, C, E, H) | Anti-IL-7R 2B8 Fab heavy chain | polymer | 225 | 24269.1 | 4 | Mus musculus (Mouse) | ||
| 2 | B, D, F, L (B, D, F, L) | anti-IL-7R 2B8 Fab light chain | polymer | 214 | 23605.3 | 4 | Mus musculus (Mouse) | ||
| 3 | G, I, J, K (G, I, J, K) | Interleukin-7 receptor subunit alpha | polymer | 223 | 25691.0 | 4 | UniProt (P16871) Pfam (PF18447) Pfam (PF00041) | Homo sapiens (Human) | IL-7RA,CDw127 |
| 4 | M, N (M, N) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | Homo sapiens (Human) | IL-7RA,CDw127 | |
| 5 | O (O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | Homo sapiens (Human) | IL-7RA,CDw127 | |
| 6 | P (G) | alpha-L-fucopyranose | non-polymer | 164.2 | 1 | Chemie (FUC) | |||
| 7 | Q, R, S, T (G, I, J, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | IL-7RA,CDw127 |
Sequence modifications
G, I, J, K: 1 - 219 (UniProt: P16871)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Thr 46 | Ile 66 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 294261.5 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1597.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1049.0 | |
| All* | Total formula weight | 296908.0 |
