6P0P
Human beta-tryptase co-crystal structure with 5-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-2-(3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-[1,1'-biphenyl]-3-yl)-2-hydroxy-2H-1,3,2-benzodioxaborol-2-uide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tryptase alpha/beta-1 | polymer | 275 | 30564.1 | 2 | UniProt (Q15661) Pfam (PF00089) | Homo sapiens (Human) | Tryptase-1,Tryptase I,Tryptase alpha-1 |
| 2 | C (A) | (3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}[1,1'-biphenyl]-3-yl){4-[3-(aminomethyl)phenyl]piperidin-1-yl}[3,4-di(hydroxy-kappaO)phenyl]methanonato(2-)hydroxyborate(1-) | non-polymer | 721.7 | 1 | Chemie (Y35) | |||
| 3 | D, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | E, I (A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 5 | H (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 275 (UniProt: Q15661)
| PDB | External Database | Details |
|---|---|---|
| Lys 132 | Asn 132 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61128.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1505.4 | |
| All* | Total formula weight | 62633.7 |
