6OPA
Crystal structure of bovine Fab NC-Cow1 in complex with HIV-1 BG505 SOSIP.664, and human Fabs 35022 and PGT128
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | G | Envelope glycoprotein gp160 | polymer | 475 | 53121.1 | 1 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
2 | B | Envelope glycoprotein gp41 | polymer | 153 | 17146.5 | 1 | UniProt (Q2N0S6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | |
3 | F | Fab 35022 heavy chain | polymer | 240 | 25783.1 | 1 | Homo sapiens | ||
4 | I | Fab 35022 light chain | polymer | 216 | 23318.8 | 1 | Homo sapiens | ||
5 | J | Fab PGT128 light chain | polymer | 211 | 22223.6 | 1 | Homo sapiens | ||
6 | K | Fab PGT128 heavy chain | polymer | 239 | 25580.7 | 1 | Homo sapiens | ||
7 | R | Fab NC-Cow1 light chain | polymer | 216 | 22633.7 | 1 | Homo sapiens | ||
8 | S | Fab NC-Cow1 heavy chain | polymer | 272 | 29357.7 | 1 | Homo sapiens | ||
9 | A | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G55220VL) | |||
10 | C, L | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
11 | D, E, Q | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
12 | H, N | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
13 | M, O, P, U | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
14 | T | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
15 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
G: 31 - 507 (UniProt: Q2N0S6)
B: 512 - 664 (UniProt: Q2N0S6)
PDB | External Database | Details |
---|---|---|
Asn 332 | Thr 330 | conflict |
Cys 501 | Ala 498 | conflict |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | engineered mutation |
Cys 605 | Thr 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 219165.2 | |
Branched | Number of molecules | 13 |
Total formula weight | 9732.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 229340.4 |