6OM2
Crystal structure of atypical integrin alphaV beta8 with proTGF-beta1 ligand peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Integrin alpha-V | polymer | 598 | 65625.6 | 2 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) In PDB | Homo sapiens (Human) | Vitronectin receptor,Vitronectin receptor subunit alpha |
2 | B, D | Integrin beta-8 | polymer | 421 | 46634.0 | 2 | UniProt (P26012) Pfam (PF17205) Pfam (PF00362) In PDB | Homo sapiens (Human) | Integrin beta subunit |
3 | E, F | proTGF-beta1 RGD peptide | polymer | 11 | 1155.3 | 2 | UniProt (by SIFTS) (P01137) In PDB | Homo sapiens | |
4 | G, K, S | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
5 | H, L, O | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 3 | In PDB GlyTouCan (G55220VL) | |||
6 | I | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
7 | J | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
8 | M, P, Q, R | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
9 | N | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
10 | B, C, D, A | CALCIUM ION | non-polymer | 40.1 | 10 | Chemie (CA) | |||
11 | D, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
12 | C, A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
13 | B, D | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
14 | C | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
15 | water | water | 18.0 | 203 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 595 (UniProt: P06756)
B, D: 1 - 421 (UniProt: P26012)
PDB | External Database | Details |
---|---|---|
Gly 400 | - | insertion |
Cys 401 | Met 430 | engineered mutation |
Thr 596 | - | expression tag |
Gly 597 | - | expression tag |
Gly 598 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Cys 259 | Val 301 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 226829.7 | |
Branched | Number of molecules | 13 |
Total formula weight | 9895.0 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 1400.3 | |
All* | Total formula weight | 238125.0 |