6OFB
Crystal structure of human glutamine-dependent NAD+ synthetase complexed with NaAD+, AMP, pyrophosphate, and Mg2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamine-dependent NAD(+) synthetase | polymer | 707 | 79481.7 | 2 | UniProt (Q6IA69) Pfam (PF00795) Pfam (PF02540) | Homo sapiens (Human) | NAD(+) synthase [glutamine-hydrolyzing],NAD(+) synthetase |
| 2 | C, L (A, B) | NICOTINIC ACID ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 2 | Chemie (DND) | |||
| 3 | D, M (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (34768) PubChem (83862) PubChem (40467049) PubChem (40469468) PubChem (446048) PubChem (44348067) PubChem (45358029) PubChem (40459109) PubChem (515384) PubChem (46874558) PubChem (638042) PubChem (46875232) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (5316444) PubChem (5742864) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (12163610) PubChem (12358355) PubChem (92144436) PubChem (122197642) PubChem (12358354) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 4 | E, N (A, B) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 2 | Chemie (POP) PubChem (4995) | |||
| 5 | F, O (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | G, H, I, J, K... (A, B) | CHLORIDE ION | non-polymer | 35.5 | 9 | Chemie (CL) PubChem (312) | |||
| 7 | T, U (A, B) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 706 (UniProt: Q6IA69)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Leu 74 | Val 74 | variant |
| His 204 | Gln 204 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 158963.4 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2744.9 | |
| All* | Total formula weight | 161708.3 |
