6OB0
Compound 2 bound structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in HEK293-F cells
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Lipoprotein lipase | polymer | 448 | 50465.1 | 4 | UniProt (P06858) Pfam (PF00151) Pfam (PF01477) In PDB | Homo sapiens (Human) | LPL |
| 2 | E, F, G, H | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 | polymer | 131 | 14727.8 | 4 | UniProt (Q8IV16) Pfam (PF00021) In PDB | Homo sapiens (Human) | GPI-anchored HDL-binding protein 1,High density lipoprotein-binding protein 1 |
| 3 | D, A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 4 | C, D, A, B | 7-(3-cyano-4-hydroxyphenyl)-N-[2-(morpholin-4-yl)ethyl]dibenzo[b,f]oxepine-10-carboxamide | non-polymer | 467.5 | 8 | Chemie (M3D) | |||
| 5 | C, D, A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 6 | C, D, A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 7 | B | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 8 | water | water | 18.0 | 226 | Chemie (HOH) |
Sequence modifications
E, F, G, H: 21 - 151 (UniProt: Q8IV16)
| PDB | External Database | Details |
|---|---|---|
| Asp 78 | Asn 78 | engineered mutation |
| Asp 82 | Asn 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 260771.6 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 6288.8 | |
| All* | Total formula weight | 267060.4 |
