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6OB0

Compound 2 bound structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in HEK293-F cells

Functional Information from GO Data
ChainGOidnamespacecontents
A0004465molecular_functionlipoprotein lipase activity
A0004620molecular_functionphospholipase activity
A0004806molecular_functiontriglyceride lipase activity
A0005102molecular_functionsignaling receptor binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006641biological_processtriglyceride metabolic process
A0006644biological_processphospholipid metabolic process
A0008201molecular_functionheparin binding
A0008970molecular_functionphospholipase A1 activity
A0009617biological_processresponse to bacterium
A0009749biological_processresponse to glucose
A0009986cellular_componentcell surface
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0010884biological_processpositive regulation of lipid storage
A0010886biological_processpositive regulation of cholesterol storage
A0010890biological_processpositive regulation of sequestering of triglyceride
A0016042biological_processlipid catabolic process
A0016298molecular_functionlipase activity
A0016787molecular_functionhydrolase activity
A0019433biological_processtriglyceride catabolic process
A0031670biological_processcellular response to nutrient
A0032722biological_processpositive regulation of chemokine production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0034185molecular_functionapolipoprotein binding
A0034361cellular_componentvery-low-density lipoprotein particle
A0034371biological_processchylomicron remodeling
A0034372biological_processvery-low-density lipoprotein particle remodeling
A0034375biological_processhigh-density lipoprotein particle remodeling
A0042627cellular_componentchylomicron
A0042632biological_processcholesterol homeostasis
A0042803molecular_functionprotein homodimerization activity
A0043395molecular_functionheparan sulfate proteoglycan binding
A0043495molecular_functionprotein-membrane adaptor activity
A0045600biological_processpositive regulation of fat cell differentiation
A0046872molecular_functionmetal ion binding
A0050729biological_processpositive regulation of inflammatory response
A0052689molecular_functioncarboxylic ester hydrolase activity
A0052739molecular_functionphosphatidylserine 1-acylhydrolase activity
A0052740molecular_function1-acyl-2-lysophosphatidylserine acylhydrolase activity
A0055096biological_processlow-density lipoprotein particle mediated signaling
A0070328biological_processtriglyceride homeostasis
A0071398biological_processcellular response to fatty acid
A0071813molecular_functionlipoprotein particle binding
A1902494cellular_componentcatalytic complex
A1904179biological_processpositive regulation of adipose tissue development
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
B0004465molecular_functionlipoprotein lipase activity
B0004620molecular_functionphospholipase activity
B0004806molecular_functiontriglyceride lipase activity
B0005102molecular_functionsignaling receptor binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0006641biological_processtriglyceride metabolic process
B0006644biological_processphospholipid metabolic process
B0008201molecular_functionheparin binding
B0008970molecular_functionphospholipase A1 activity
B0009617biological_processresponse to bacterium
B0009749biological_processresponse to glucose
B0009986cellular_componentcell surface
B0010744biological_processpositive regulation of macrophage derived foam cell differentiation
B0010884biological_processpositive regulation of lipid storage
B0010886biological_processpositive regulation of cholesterol storage
B0010890biological_processpositive regulation of sequestering of triglyceride
B0016042biological_processlipid catabolic process
B0016298molecular_functionlipase activity
B0016787molecular_functionhydrolase activity
B0019433biological_processtriglyceride catabolic process
B0031670biological_processcellular response to nutrient
B0032722biological_processpositive regulation of chemokine production
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032755biological_processpositive regulation of interleukin-6 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0034185molecular_functionapolipoprotein binding
B0034361cellular_componentvery-low-density lipoprotein particle
B0034371biological_processchylomicron remodeling
B0034372biological_processvery-low-density lipoprotein particle remodeling
B0034375biological_processhigh-density lipoprotein particle remodeling
B0042627cellular_componentchylomicron
B0042632biological_processcholesterol homeostasis
B0042803molecular_functionprotein homodimerization activity
B0043395molecular_functionheparan sulfate proteoglycan binding
B0043495molecular_functionprotein-membrane adaptor activity
B0045600biological_processpositive regulation of fat cell differentiation
B0046872molecular_functionmetal ion binding
B0050729biological_processpositive regulation of inflammatory response
B0052689molecular_functioncarboxylic ester hydrolase activity
B0052739molecular_functionphosphatidylserine 1-acylhydrolase activity
B0052740molecular_function1-acyl-2-lysophosphatidylserine acylhydrolase activity
B0055096biological_processlow-density lipoprotein particle mediated signaling
B0070328biological_processtriglyceride homeostasis
B0071398biological_processcellular response to fatty acid
B0071813molecular_functionlipoprotein particle binding
B1902494cellular_componentcatalytic complex
B1904179biological_processpositive regulation of adipose tissue development
B2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
C0004465molecular_functionlipoprotein lipase activity
C0004620molecular_functionphospholipase activity
C0004806molecular_functiontriglyceride lipase activity
C0005102molecular_functionsignaling receptor binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0006633biological_processfatty acid biosynthetic process
C0006641biological_processtriglyceride metabolic process
C0006644biological_processphospholipid metabolic process
C0008201molecular_functionheparin binding
C0008970molecular_functionphospholipase A1 activity
C0009617biological_processresponse to bacterium
C0009749biological_processresponse to glucose
C0009986cellular_componentcell surface
C0010744biological_processpositive regulation of macrophage derived foam cell differentiation
C0010884biological_processpositive regulation of lipid storage
C0010886biological_processpositive regulation of cholesterol storage
C0010890biological_processpositive regulation of sequestering of triglyceride
C0016042biological_processlipid catabolic process
C0016298molecular_functionlipase activity
C0016787molecular_functionhydrolase activity
C0019433biological_processtriglyceride catabolic process
C0031670biological_processcellular response to nutrient
C0032722biological_processpositive regulation of chemokine production
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032755biological_processpositive regulation of interleukin-6 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0034185molecular_functionapolipoprotein binding
C0034361cellular_componentvery-low-density lipoprotein particle
C0034371biological_processchylomicron remodeling
C0034372biological_processvery-low-density lipoprotein particle remodeling
C0034375biological_processhigh-density lipoprotein particle remodeling
C0042627cellular_componentchylomicron
C0042632biological_processcholesterol homeostasis
C0042803molecular_functionprotein homodimerization activity
C0043395molecular_functionheparan sulfate proteoglycan binding
C0043495molecular_functionprotein-membrane adaptor activity
C0045600biological_processpositive regulation of fat cell differentiation
C0046872molecular_functionmetal ion binding
C0050729biological_processpositive regulation of inflammatory response
C0052689molecular_functioncarboxylic ester hydrolase activity
C0052739molecular_functionphosphatidylserine 1-acylhydrolase activity
C0052740molecular_function1-acyl-2-lysophosphatidylserine acylhydrolase activity
C0055096biological_processlow-density lipoprotein particle mediated signaling
C0070328biological_processtriglyceride homeostasis
C0071398biological_processcellular response to fatty acid
C0071813molecular_functionlipoprotein particle binding
C1902494cellular_componentcatalytic complex
C1904179biological_processpositive regulation of adipose tissue development
C2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
D0004465molecular_functionlipoprotein lipase activity
D0004620molecular_functionphospholipase activity
D0004806molecular_functiontriglyceride lipase activity
D0005102molecular_functionsignaling receptor binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0006629biological_processlipid metabolic process
D0006631biological_processfatty acid metabolic process
D0006633biological_processfatty acid biosynthetic process
D0006641biological_processtriglyceride metabolic process
D0006644biological_processphospholipid metabolic process
D0008201molecular_functionheparin binding
D0008970molecular_functionphospholipase A1 activity
D0009617biological_processresponse to bacterium
D0009749biological_processresponse to glucose
D0009986cellular_componentcell surface
D0010744biological_processpositive regulation of macrophage derived foam cell differentiation
D0010884biological_processpositive regulation of lipid storage
D0010886biological_processpositive regulation of cholesterol storage
D0010890biological_processpositive regulation of sequestering of triglyceride
D0016042biological_processlipid catabolic process
D0016298molecular_functionlipase activity
D0016787molecular_functionhydrolase activity
D0019433biological_processtriglyceride catabolic process
D0031670biological_processcellular response to nutrient
D0032722biological_processpositive regulation of chemokine production
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032755biological_processpositive regulation of interleukin-6 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0034185molecular_functionapolipoprotein binding
D0034361cellular_componentvery-low-density lipoprotein particle
D0034371biological_processchylomicron remodeling
D0034372biological_processvery-low-density lipoprotein particle remodeling
D0034375biological_processhigh-density lipoprotein particle remodeling
D0042627cellular_componentchylomicron
D0042632biological_processcholesterol homeostasis
D0042803molecular_functionprotein homodimerization activity
D0043395molecular_functionheparan sulfate proteoglycan binding
D0043495molecular_functionprotein-membrane adaptor activity
D0045600biological_processpositive regulation of fat cell differentiation
D0046872molecular_functionmetal ion binding
D0050729biological_processpositive regulation of inflammatory response
D0052689molecular_functioncarboxylic ester hydrolase activity
D0052739molecular_functionphosphatidylserine 1-acylhydrolase activity
D0052740molecular_function1-acyl-2-lysophosphatidylserine acylhydrolase activity
D0055096biological_processlow-density lipoprotein particle mediated signaling
D0070328biological_processtriglyceride homeostasis
D0071398biological_processcellular response to fatty acid
D0071813molecular_functionlipoprotein particle binding
D1902494cellular_componentcatalytic complex
D1904179biological_processpositive regulation of adipose tissue development
D2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. VHLLGYSLGA
ChainResidueDetails
AVAL153-ALA162

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:29899144
ChainResidueDetails
ETYR38
FTYR38
GTYR38
HTYR38

site_idSWS_FT_FI2
Number of Residues4
DetailsLIPID: GPI-anchor amidated glycine => ECO:0000250|UniProtKB:Q9D1N2
ChainResidueDetails
EGLY151
FGLY151
GGLY151
HGLY151
CASP183
CHIS268
DASP183
DHIS268

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29899144, ECO:0000269|PubMed:30559189, ECO:0007744|PDB:6E7K
ChainResidueDetails
EASP78
CARG197
CSER199
CASP202
DALA194
DARG197
DSER199
DASP202
FASP78
GASP78
HASP78
BALA194
BARG197
BSER199
BASP202
CALA194

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q06000
ChainResidueDetails
ATYR121
DTYR121
DTYR191
DTYR343
ATYR191
ATYR343
BTYR121
BTYR191
BTYR343
CTYR121
CTYR191
CTYR343

site_idSWS_FT_FI5
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:30559189, ECO:0007744|PDB:6E7K
ChainResidueDetails
AASN70
BASN70
CASN70
DASN70

site_idSWS_FT_FI6
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30559189, ECO:0007744|PDB:6E7K
ChainResidueDetails
AASN386
BASN386
CASN386
DASN386

222415

PDB entries from 2024-07-10

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