6O4D
Structure of ALDH7A1 mutant W175A complexed with L-pipecolic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Alpha-aminoadipic semialdehyde dehydrogenase | polymer | 513 | 55521.2 | 1 | UniProt (P49419) Pfam (PF00171) | Homo sapiens (Human) | ALDH7A1, Alpha-AASA dehydrogenase,Aldehyde dehydrogenase family 7 member A1,Antiquitin-1,Betaine aldehyde dehydrogenase,Delta1-piperideine-6-carboxylate dehydrogenase,P6c dehydrogenase, |
| 2 | B, G (B, G) | Alpha-aminoadipic semialdehyde dehydrogenase | polymer | 513 | 55553.2 | 2 | UniProt (P49419) Pfam (PF00171) | Homo sapiens (Human) | ALDH7A1, Alpha-AASA dehydrogenase,Aldehyde dehydrogenase family 7 member A1,Antiquitin-1,Betaine aldehyde dehydrogenase,Delta1-piperideine-6-carboxylate dehydrogenase,P6c dehydrogenase |
| 3 | C, D, E, F, H (C, D, E, F, H) | Alpha-aminoadipic semialdehyde dehydrogenase | polymer | 513 | 55505.2 | 5 | UniProt (P49419) Pfam (PF00171) | Homo sapiens (Human) | ALDH7A1, Alpha-AASA dehydrogenase,Aldehyde dehydrogenase family 7 member A1,Antiquitin-1,Betaine aldehyde dehydrogenase,Delta1-piperideine-6-carboxylate dehydrogenase,P6c dehydrogenase |
| 4 | AA, I, K, N, P... (H, A, B, C, D...) | PYRIDINE-2-CARBOXYLIC ACID | non-polymer | 123.1 | 8 | Chemie (6PC) | |||
| 5 | CA, EA, J, Q, T... (H, A, D, E) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 6 | Chemie (PGE) | |||
| 6 | L, X (B, F) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 7 | M (B) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 8 | DA, O, R, W, Z (H, C, D, F, G) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 5 | Chemie (PG4) | |||
| 9 | BA (H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 10 | FA, GA, HA, IA, JA... (A, B, C, D, E...) | water | water | 18.0 | 2055 | Chemie (HOH) |
Sequence modifications
A: 1 - 511 (UniProt: P49419)
B, G: 1 - 511 (UniProt: P49419)
C, D, E, F, H: 1 - 511 (UniProt: P49419)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 175 | Trp 203 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 175 | Trp 203 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 175 | Trp 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 444153.9 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 3369.6 | |
| All* | Total formula weight | 447523.5 |
