Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6O4D

Structure of ALDH7A1 mutant W175A complexed with L-pipecolic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006081	biological_process	cellular aldehyde metabolic process
A	0007605	biological_process	sensory perception of sound
A	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0019285	biological_process	glycine betaine biosynthetic process from choline
A	0042426	biological_process	choline catabolic process
A	0042802	molecular_function	identical protein binding
A	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
A	0070062	cellular_component	extracellular exosome
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006081	biological_process	cellular aldehyde metabolic process
B	0007605	biological_process	sensory perception of sound
B	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0019285	biological_process	glycine betaine biosynthetic process from choline
B	0042426	biological_process	choline catabolic process
B	0042802	molecular_function	identical protein binding
B	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
B	0070062	cellular_component	extracellular exosome
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006081	biological_process	cellular aldehyde metabolic process
C	0007605	biological_process	sensory perception of sound
C	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0019285	biological_process	glycine betaine biosynthetic process from choline
C	0042426	biological_process	choline catabolic process
C	0042802	molecular_function	identical protein binding
C	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
C	0070062	cellular_component	extracellular exosome
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006081	biological_process	cellular aldehyde metabolic process
D	0007605	biological_process	sensory perception of sound
D	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0019285	biological_process	glycine betaine biosynthetic process from choline
D	0042426	biological_process	choline catabolic process
D	0042802	molecular_function	identical protein binding
D	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
D	0070062	cellular_component	extracellular exosome
E	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
E	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006081	biological_process	cellular aldehyde metabolic process
E	0007605	biological_process	sensory perception of sound
E	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0019285	biological_process	glycine betaine biosynthetic process from choline
E	0042426	biological_process	choline catabolic process
E	0042802	molecular_function	identical protein binding
E	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
E	0070062	cellular_component	extracellular exosome
F	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
F	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005829	cellular_component	cytosol
F	0006081	biological_process	cellular aldehyde metabolic process
F	0007605	biological_process	sensory perception of sound
F	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0019285	biological_process	glycine betaine biosynthetic process from choline
F	0042426	biological_process	choline catabolic process
F	0042802	molecular_function	identical protein binding
F	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
F	0070062	cellular_component	extracellular exosome
G	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
G	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0006081	biological_process	cellular aldehyde metabolic process
G	0007605	biological_process	sensory perception of sound
G	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0019285	biological_process	glycine betaine biosynthetic process from choline
G	0042426	biological_process	choline catabolic process
G	0042802	molecular_function	identical protein binding
G	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
G	0070062	cellular_component	extracellular exosome
H	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
H	0004043	molecular_function	L-aminoadipate-semialdehyde dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005829	cellular_component	cytosol
H	0006081	biological_process	cellular aldehyde metabolic process
H	0007605	biological_process	sensory perception of sound
H	0008802	molecular_function	betaine-aldehyde dehydrogenase (NAD+) activity
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0019285	biological_process	glycine betaine biosynthetic process from choline
H	0042426	biological_process	choline catabolic process
H	0042802	molecular_function	identical protein binding
H	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
H	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 6PC A 601

Chain	Residue
A	GLU121
A	PHE168
A	ARG301
A	THR303
A	GLY461
A	ALA462
A	PHE468
A	HOH803
A	HOH895

site_id	AC2
Number of Residues	4
Details	binding site for residue PGE A 602

Chain	Residue
A	ARG68
A	TRP71
A	GLU237
A	ASN240

site_id	AC3
Number of Residues	10
Details	binding site for residue 6PC B 601

Chain	Residue
B	GLU121
B	PHE168
B	ARG301
B	THR303
B	GLY461
B	ALA462
B	PHE468
B	HOH741
B	HOH864
B	HOH914

site_id	AC4
Number of Residues	4
Details	binding site for residue PEG B 602

Chain	Residue
B	GLY230
B	THR231
B	VAL250
B	HOH906

site_id	AC5
Number of Residues	7
Details	binding site for residue 1PE B 603

Chain	Residue
B	ARG68
B	TRP71
B	GLU237
B	ARG238
B	ASN240
B	HOH829
B	HOH848

site_id	AC6
Number of Residues	8
Details	binding site for residue 6PC C 601

Chain	Residue
C	GLU121
C	PHE168
C	ARG301
C	THR303
C	GLY461
C	ALA462
C	PHE468
C	HOH847

site_id	AC7
Number of Residues	5
Details	binding site for residue PG4 C 602

Chain	Residue
C	ARG68
C	TRP71
C	VAL157
C	GLU237
C	ASN240

site_id	AC8
Number of Residues	8
Details	binding site for residue 6PC D 601

Chain	Residue
D	GLU121
D	PHE168
D	ARG301
D	THR303
D	GLY461
D	ALA462
D	PHE468
D	HOH859

site_id	AC9
Number of Residues	8
Details	binding site for residue PGE D 602

Chain	Residue
D	ILE163
D	LYS190
D	GLY230
D	THR231
D	PHE244
D	VAL250
D	HOH740
D	HOH878

site_id	AD1
Number of Residues	4
Details	binding site for residue PG4 D 603

Chain	Residue
D	ARG68
D	TRP71
D	GLU237
D	ASN240

site_id	AD2
Number of Residues	9
Details	binding site for residue 6PC E 601

Chain	Residue
E	GLU121
E	PHE168
E	ARG301
E	THR303
E	GLY461
E	ALA462
E	PHE468
E	HOH798
E	HOH816

site_id	AD3
Number of Residues	5
Details	binding site for residue PGE E 602

Chain	Residue
E	ARG68
E	TRP71
E	GLU237
E	ASN240
E	HOH917

site_id	AD4
Number of Residues	6
Details	binding site for residue PGE E 603

Chain	Residue
E	LYS190
E	GLY230
E	THR231
E	VAL250
E	GLN253
E	VAL254

site_id	AD5
Number of Residues	9
Details	binding site for residue 6PC F 601

Chain	Residue
F	GLU121
F	PHE168
F	ARG301
F	THR303
F	GLY461
F	ALA462
F	PHE468
F	HOH754
F	HOH901

site_id	AD6
Number of Residues	4
Details	binding site for residue PG4 F 602

Chain	Residue
F	ASN240
F	ARG68
F	TRP71
F	GLU237

site_id	AD7
Number of Residues	2
Details	binding site for residue PEG F 603

Chain	Residue
F	TYR128
F	SER482

site_id	AD8
Number of Residues	10
Details	binding site for residue 6PC G 601

Chain	Residue
G	GLU121
G	PHE168
G	ARG301
G	THR303
G	GLY461
G	ALA462
G	PHE468
G	HOH750
G	HOH872
G	HOH930

site_id	AD9
Number of Residues	4
Details	binding site for residue PG4 G 602

Chain	Residue
G	ARG68
G	TRP71
G	ASN240
G	HOH839

site_id	AE1
Number of Residues	10
Details	binding site for residue 6PC H 601

Chain	Residue
H	GLU121
H	PHE168
H	ARG301
H	THR303
H	GLY461
H	ALA462
H	PHE468
H	HOH755
H	HOH799
H	HOH916

site_id	AE2
Number of Residues	2
Details	binding site for residue EDO H 602

Chain	Residue
H	LEU132
H	TRP485

site_id	AE3
Number of Residues	7
Details	binding site for residue PGE H 603

Chain	Residue
B	SER30
H	TYR326
H	ALA327
H	ILE329
H	VAL331
H	TYR369
H	PRO383

site_id	AE4
Number of Residues	4
Details	binding site for residue PG4 H 604

Chain	Residue
H	ARG68
H	TRP71
H	ASN240
H	HOH712

site_id	AE5
Number of Residues	10
Details	binding site for residue PGE H 605

Chain	Residue
H	ILE163
H	GLY230
H	THR231
H	PHE244
H	VAL250
H	GLN253
H	VAL254
H	MET257
H	HOH711
H	HOH714

Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGNNA

Chain	Residue	Details
B	LEU267-ALA274
A	LEU267-ALA274
C	LEU267-ALA274

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU10007

Chain	Residue	Details
C	GLU268
D	GLU268
E	GLU268
F	GLU268
H	GLU268

site_id	SWS_FT_FI2
Number of Residues	5
Details	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:26260980

Chain	Residue	Details
C	CYS302
D	CYS302
E	CYS302
F	CYS302
H	CYS302

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269\|PubMed:20207735, ECO:0000269\|PubMed:26260980, ECO:0007744\|PDB:2J6L, ECO:0007744\|PDB:4X0T, ECO:0007744\|PDB:4ZUK, ECO:0007744\|PDB:4ZVY

Chain	Residue	Details
C	THR164
E	LYS190
E	GLY230
E	GLY246
F	THR164
F	LYS190
F	GLY230
F	GLY246
H	THR164
H	LYS190
H	GLY230
C	LYS190
H	GLY246
C	GLY230
C	GLY246
D	THR164
D	LYS190
D	GLY230
D	GLY246
E	THR164

site_id	SWS_FT_FI4
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269\|PubMed:20207735, ECO:0000269\|PubMed:26260980, ECO:0007744\|PDB:2J6L, ECO:0007744\|PDB:4X0T

Chain	Residue	Details
C	GLU268
H	GLU399
C	GLU399
D	GLU268
D	GLU399
E	GLU268
E	GLU399
F	GLU268
F	GLU399
H	GLU268

site_id	SWS_FT_FI5
Number of Residues	15
Details	BINDING: BINDING => ECO:0007744\|PDB:4ZUL

Chain	Residue	Details
C	THR303
F	THR303
F	GLY461
F	ALA462
H	THR303
H	GLY461
H	ALA462
C	GLY461
C	ALA462
D	THR303
D	GLY461
D	ALA462
E	THR303
E	GLY461
E	ALA462

site_id	SWS_FT_FI6
Number of Residues	5
Details	SITE: Transition state stabilizer => ECO:0000250

Chain	Residue	Details
C	ASN167
D	ASN167
E	ASN167
F	ASN167
H	ASN167

site_id	SWS_FT_FI7
Number of Residues	5
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9DBF1

Chain	Residue	Details
C	LYS66
D	LYS66
E	LYS66
F	LYS66
H	LYS66

site_id	SWS_FT_FI8
Number of Residues	10
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9DBF1

Chain	Residue	Details
C	LYS434
H	LYS472
C	LYS472
D	LYS434
D	LYS472
E	LYS434
E	LYS472
F	LYS434
F	LYS472
H	LYS434

site_id	SWS_FT_FI9
Number of Residues	5
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q9DBF1

Chain	Residue	Details
C	LYS509
D	LYS509
E	LYS509
F	LYS509
H	LYS509

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)