6O0T

Crystal structure of selenomethionine labelled tandem SAM domains (L446M:L505M:L523M mutant) from human SARM1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Sterile alpha and TIR motif-containing protein 1	polymer	177	20598.2	8	UniProt (Q6SZW1) Pfam (PF07647)	Homo sapiens (Human)	Sterile alpha and Armadillo repeat protein,Sterile alpha motif domain-containing protein 2,SAM domain-containing protein 2,Tir-1 homolog

Sequence modifications

A, B, C, D, E, F, G, H: 409 - 561 (UniProt: Q6SZW1)

PDB	External Database	Details
Mse 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag
His 391	-	expression tag
Ser 392	-	expression tag
Ser 393	-	expression tag
Gly 394	-	expression tag
Val 395	-	expression tag
Asp 396	-	expression tag
Leu 397	-	expression tag
Gly 398	-	expression tag
Thr 399	-	expression tag
Glu 400	-	expression tag
Asn 401	-	expression tag
Leu 402	-	expression tag
Tyr 403	-	expression tag
Phe 404	-	expression tag
Gln 405	-	expression tag
Ser 406	-	expression tag
Asn 407	-	expression tag
Ala 408	-	expression tag
Mse 446	Leu 446	engineered mutation
Mse 505	Leu 505	engineered mutation
Mse 523	Leu 523	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	164786.0
All*	Total formula weight	164786.0

*Water molecules are not included.