6O03
Monobody (MC17) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (B, A) | E3 ubiquitin-protein ligase CBL | polymer | 309 | 35862.5 | 2 | UniProt (P22681) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) | Homo sapiens (Human) | Casitas B-lineage lymphoma proto-oncogene,Proto-oncogene c-Cbl,RING finger protein 55,RING-type E3 ubiquitin transferase CBL,Signal transduction protein CBL |
| 2 | B, D (C, D) | Monobody (MC17) | polymer | 92 | 9865.1 | 2 | synthetic construct |
Sequence modifications
B, A: 47 - 353 (UniProt: P22681)
| PDB | External Database | Details |
|---|---|---|
| Gly 45 | - | expression tag |
| Ser 46 | - | expression tag |
| Glu 306 | Gly 306 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 91455.1 | |
| All* | Total formula weight | 91455.1 |
