6NT2
type 1 PRMT in complex with the inhibitor GSK3368715
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, B, C) | Protein arginine N-methyltransferase 1 | polymer | 371 | 42511.6 | 4 | UniProt (Q99873) Pfam (PF13649) Pfam (PF22528) | Homo sapiens (Human) | Histone-arginine N-methyltransferase PRMT1,Interferon receptor 1-bound protein 4 |
| 2 | E, EA, N, V (A, C, D, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
| 3 | F, FA, O, W (A, C, D, B) | N~1~-({5-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl}methyl)-N~1~,N~2~-dimethylethane-1,2-diamine | non-polymer | 366.5 | 4 | Chemie (KZS) | |||
| 4 | AA, BA, CA, G, GA... (B, A, C, D) | GLYCEROL | non-polymer | 92.1 | 23 | Chemie (GOL) | |||
| 5 | DA (B) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 6 | KA, LA, MA, NA (A, D, B, C) | water | water | 18.0 | 664 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170046.2 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 5276.2 | |
| All* | Total formula weight | 175322.4 |
