6NT2

type 1 PRMT in complex with the inhibitor GSK3368715

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, B, C	Protein arginine N-methyltransferase 1	polymer	371	42511.6	4	UniProt (Q99873) Pfam (PF13649) In PDB	Homo sapiens (Human)	Histone-arginine N-methyltransferase PRMT1,Interferon receptor 1-bound protein 4
2	A, C, D, B	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	4	Chemie (SAH)
3	A, C, D, B	N~1~-({5-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl}methyl)-N~1~,N~2~-dimethylethane-1,2-diamine	non-polymer		366.5	4	Chemie (KZS)
4	B, A, C, D	GLYCEROL	non-polymer		92.1	23	Chemie (GOL)
5	B	2,3-DIHYDROXY-1,4-DITHIOBUTANE	non-polymer		154.3	1	Chemie (DTT)
6		water	water		18.0	664	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170046.2
Non-Polymers*	Number of molecules	32
	Total formula weight	5276.2
All*	Total formula weight	175322.4

*Water molecules are not included.