6NQ3

Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Histone-binding protein RBBP4	polymer	439	49367.4	2	UniProt (Q09028) Pfam (PF12265) Pfam (PF00400) In PDB	Homo sapiens (Human)	Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48
2	B, F	Polycomb protein SUZ12	polymer	478	55686.2	2	UniProt (Q15022) In PDB	Homo sapiens (Human)	Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
3	C, G	PHD finger protein 19	polymer	84	9092.8	2	UniProt (Q5T6S3) Pfam (PF14061) In PDB	Homo sapiens (Human)	Polycomb-like protein 3,hPCL3
4	D, H	Protein Jumonji	polymer	19	2257.7	2	UniProt (Q92833) In PDB	Homo sapiens	Jumonji/ARID domain-containing protein 2
5	B, F	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A, E: 1 - 425 (UniProt: Q09028)

PDB	External Database	Details
Met -13	-	initiating methionine
Ser -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Leu -5	-	expression tag
Val -4	-	expression tag
Pro -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B, F: 76 - 545 (UniProt: Q15022)

PDB	External Database	Details
Trp 546	-	expression tag
Ser 547	-	expression tag
His 548	-	expression tag
Pro 549	-	expression tag
Gln 550	-	expression tag
Phe 551	-	expression tag
Glu 552	-	expression tag
Lys 553	-	expression tag

C, G: 500 - 580 (UniProt: Q5T6S3)

PDB	External Database	Details
Ser 497	-	expression tag
Asn 498	-	expression tag
Ala 499	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	232808.2
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	232939.0

*Water molecules are not included.