Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NQ3

Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0006335	biological_process	DNA replication-dependent chromatin assembly
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0007420	biological_process	brain development
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016581	cellular_component	NuRD complex
A	0016589	cellular_component	NURF complex
A	0030336	biological_process	negative regulation of cell migration
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0031492	molecular_function	nucleosomal DNA binding
A	0032991	cellular_component	protein-containing complex
A	0033186	cellular_component	CAF-1 complex
A	0035098	cellular_component	ESC/E(Z) complex
A	0042393	molecular_function	histone binding
A	0042659	biological_process	regulation of cell fate specification
A	0042826	molecular_function	histone deacetylase binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0070822	cellular_component	Sin3-type complex
A	1902455	biological_process	negative regulation of stem cell population maintenance
A	1902459	biological_process	positive regulation of stem cell population maintenance
A	1904949	cellular_component	ATPase complex
A	2000736	biological_process	regulation of stem cell differentiation
E	0000118	cellular_component	histone deacetylase complex
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0006335	biological_process	DNA replication-dependent chromatin assembly
E	0006338	biological_process	chromatin remodeling
E	0006355	biological_process	regulation of DNA-templated transcription
E	0007420	biological_process	brain development
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016581	cellular_component	NuRD complex
E	0016589	cellular_component	NURF complex
E	0030336	biological_process	negative regulation of cell migration
E	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
E	0031492	molecular_function	nucleosomal DNA binding
E	0032991	cellular_component	protein-containing complex
E	0033186	cellular_component	CAF-1 complex
E	0035098	cellular_component	ESC/E(Z) complex
E	0042393	molecular_function	histone binding
E	0042659	biological_process	regulation of cell fate specification
E	0042826	molecular_function	histone deacetylase binding
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0070822	cellular_component	Sin3-type complex
E	1902455	biological_process	negative regulation of stem cell population maintenance
E	1902459	biological_process	positive regulation of stem cell population maintenance
E	1904949	cellular_component	ATPase complex
E	2000736	biological_process	regulation of stem cell differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 1001

Chain	Residue
B	CYS450
B	CYS453
B	HIS466
B	HIS471

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN F 1001

Chain	Residue
F	CYS450
F	CYS453
F	HIS466
F	HIS471

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI

Chain	Residue	Details
A	LEU193-ILE207
A	LEU289-LEU303
A	LEU333-LEU347

site_id	PS00028
Number of Residues	22
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpw..CtlnCrklysllkHlklc.H

Chain	Residue	Details
B	CYS450-HIS471

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	ZN_FING: C2H2-type

Chain	Residue	Details
B	LEU448-HIS471
F	LEU448-HIS471

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Breakpoint for translocation to form JAZF1-SUZ12 oncogene

Chain	Residue	Details
B	PRO93
F	PRO93

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
B	SER541
F	SER541

site_id	SWS_FT_FI4
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
F	LYS390
B	LYS223
E	LYS160
B	LYS390
F	LYS223

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER355
E	SER355

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
A	LYS4
E	LYS4

site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:25755297, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS160
E	LYS160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)