6NN8

The structure of human liver pyruvate kinase, hLPYK-S531E

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Pyruvate kinase PKLR	polymer	543	58606.2	8	UniProt (P30613) Pfam (PF00224) Pfam (PF02887)	Homo sapiens (Human)	Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase
2	AA, BA, CA, DA, EA... (C, D, A, E, F...)	1,2-ETHANEDIOL	non-polymer		62.1	41	Chemie (EDO)
3	AB, BB, CB, DB, EB... (D, E, F, G, H...)	water	water		18.0	250	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 3 - 543 (UniProt: P30613)

PDB	External Database	Details
Met 1	-	expression tag
Glu 2	-	expression tag
Glu 531	Ser 562	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	468849.6
Non-Polymers*	Number of molecules	41
	Total formula weight	2544.8
All*	Total formula weight	471394.4

*Water molecules are not included.