6NN4
The structure of human liver pyruvate kinase, hLPYK-D499N, in complex with Fru-1,6-BP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Pyruvate kinase PKLR | polymer | 543 | 58563.2 | 4 | UniProt (P30613) Pfam (PF00224) Pfam (PF02887) In PDB | Homo sapiens (Human) | Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase |
| 2 | A, B, C, D | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 4 | Chemie (FBP) | |||
| 3 | A, B, C, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 4 | A, B, C, D | PHOSPHOENOLPYRUVATE | non-polymer | 168.0 | 4 | Chemie (PEP) | |||
| 5 | water | water | 18.0 | 353 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 543 (UniProt: P30613)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Glu 2 | - | expression tag |
| Asn 499 | Asp 530 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 234252.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2467.1 | |
| All* | Total formula weight | 236719.8 |
