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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6NN4

The structure of human liver pyruvate kinase, hLPYK-D499N, in complex with Fru-1,6-BP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0001666biological_processresponse to hypoxia
A0003824molecular_functioncatalytic activity
A0004743molecular_functionpyruvate kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006096biological_processglycolytic process
A0007584biological_processresponse to nutrient
A0009749biological_processresponse to glucose
A0010038biological_processresponse to metal ion
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0030955molecular_functionpotassium ion binding
A0032869biological_processcellular response to insulin stimulus
A0033198biological_processresponse to ATP
A0042866biological_processpyruvate biosynthetic process
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0051591biological_processresponse to cAMP
A0070062cellular_componentextracellular exosome
A0071872biological_processcellular response to epinephrine stimulus
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0001666biological_processresponse to hypoxia
B0003824molecular_functioncatalytic activity
B0004743molecular_functionpyruvate kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006096biological_processglycolytic process
B0007584biological_processresponse to nutrient
B0009749biological_processresponse to glucose
B0010038biological_processresponse to metal ion
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0030955molecular_functionpotassium ion binding
B0032869biological_processcellular response to insulin stimulus
B0033198biological_processresponse to ATP
B0042866biological_processpyruvate biosynthetic process
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0051591biological_processresponse to cAMP
B0070062cellular_componentextracellular exosome
B0071872biological_processcellular response to epinephrine stimulus
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0001666biological_processresponse to hypoxia
C0003824molecular_functioncatalytic activity
C0004743molecular_functionpyruvate kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006096biological_processglycolytic process
C0007584biological_processresponse to nutrient
C0009749biological_processresponse to glucose
C0010038biological_processresponse to metal ion
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0030955molecular_functionpotassium ion binding
C0032869biological_processcellular response to insulin stimulus
C0033198biological_processresponse to ATP
C0042866biological_processpyruvate biosynthetic process
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0051591biological_processresponse to cAMP
C0070062cellular_componentextracellular exosome
C0071872biological_processcellular response to epinephrine stimulus
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0001666biological_processresponse to hypoxia
D0003824molecular_functioncatalytic activity
D0004743molecular_functionpyruvate kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006096biological_processglycolytic process
D0007584biological_processresponse to nutrient
D0009749biological_processresponse to glucose
D0010038biological_processresponse to metal ion
D0016301molecular_functionkinase activity
D0016740molecular_functiontransferase activity
D0030955molecular_functionpotassium ion binding
D0032869biological_processcellular response to insulin stimulus
D0033198biological_processresponse to ATP
D0042866biological_processpyruvate biosynthetic process
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0051591biological_processresponse to cAMP
D0070062cellular_componentextracellular exosome
D0071872biological_processcellular response to epinephrine stimulus
Functional Information from PROSITE/UniProt
site_idPS00110
Number of Residues13
DetailsPYRUVATE_KINASE Pyruvate kinase active site signature. IkIISKIENhEGV
ChainResidueDetails
AILE277-VAL289
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11960989","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VGB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues13
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues70
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11960989","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VGF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P00549","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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