6NMI
Cryo-EM structure of the human TFIIH core complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | General transcription and DNA repair factor IIH helicase subunit XPB | polymer | 653 | 74233.5 | 1 | Pfam (PF13625) Pfam (PF04851) Pfam (PF16203) UniProt (by SIFTS) (P19447) In PDB | Homo sapiens (Human) | |
| 2 | B | General transcription and DNA repair factor IIH helicase subunit XPD | polymer | 760 | 86417.8 | 1 | Pfam (PF06733) Pfam (PF06777) Pfam (PF13307) UniProt (by SIFTS) (P18074) In PDB | Homo sapiens (Human) | |
| 3 | C | General transcription factor IIH subunit 1, p62 | polymer | 548 | 57789.0 | 1 | Pfam (PF08567) Pfam (PF03909) UniProt (by SIFTS) (P32780) In PDB | Homo sapiens (Human) | |
| 4 | D | General transcription factor IIH subunit 4, p52 | polymer | 462 | 52245.2 | 1 | UniProt (Q92759) Pfam (PF18307) Pfam (PF03849) In PDB | Homo sapiens (Human) | Basic transcription factor 2 52 kDa subunit, BTF2 p52, General transcription factor IIH polypeptide 4, TFIIH basal transcription factor complex p52 subunit |
| 5 | E | General transcription factor IIH subunit 2, p44 | polymer | 366 | 39609.1 | 1 | Pfam (PF04056) Pfam (PF07975) UniProt (by SIFTS) (Q13888) In PDB | Homo sapiens (Human) | |
| 6 | F | General transcription factor IIH subunit 3, p34 | polymer | 308 | 34416.0 | 1 | UniProt (Q13889) Pfam (PF03850) In PDB | Homo sapiens (Human) | p34, BASIC TRANSCRIPTION FACTOR 2 34 KDA SUBUNIT, BTF2 P34, GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 3, TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX P34 SUBUNIT |
| 7 | G | General transcription factor IIH subunit 5, p8 | polymer | 71 | 8060.4 | 1 | UniProt (Q6ZYL4) Pfam (PF06331) In PDB | Homo sapiens (Human) | General transcription factor IIH polypeptide 5, TFB5 ortholog, TFIIH basal transcription factor complex TTD-A subunit |
| 8 | H | CDK-activating kinase assembly factor MAT1 | polymer | 309 | 35874.0 | 1 | UniProt (P51948) Pfam (PF17121) Pfam (PF06391) In PDB | Homo sapiens (Human) | CDK7/cyclin-H assembly factor,Cyclin-G1-interacting protein,Menage a trois,RING finger protein 66,RING finger protein MAT1,p35,p36 |
| 9 | B | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 10 | E, F, H | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 388644.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 744.1 | |
| All* | Total formula weight | 389388.9 |
