6NIY
A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45725.5 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
2 | N | Nanobody35 | polymer | 138 | 15140.7 | 1 | Lama glama (llama) | ||
3 | R | Calcitonin receptor | polymer | 474 | 55387.3 | 1 | UniProt (P30988) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (Human) | CT-R |
4 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
5 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
6 | P | Calcitonin | polymer | 32 | 3438.9 | 1 | UniProt (Q92163) Pfam (PF00214) In PDB | Oncorhynchus sp. |
Sequence modifications
R: 1 - 474 (UniProt: P30988)
PDB | External Database | Details |
---|---|---|
- | Lys 193 | deletion |
- | Leu 194 | deletion |
- | Thr 195 | deletion |
- | Thr 196 | deletion |
- | Ile 197 | deletion |
- | Phe 198 | deletion |
- | Pro 199 | deletion |
- | Leu 200 | deletion |
- | Asn 201 | deletion |
- | Trp 202 | deletion |
- | Lys 203 | deletion |
- | Tyr 204 | deletion |
- | Arg 205 | deletion |
- | Lys 206 | deletion |
- | Ala 207 | deletion |
- | Leu 208 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 164970.5 | |
All* | Total formula weight | 164970.5 |