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6NFM

Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
DNA dC->dU-editing enzyme APOBEC-3Bpolymer19322844.81UniProt (Q9UH17)
Pfam (PF05240)
Homo sapiens (Human)A3B,Phorbolin-1-related protein,Phorbolin-2/3
2B
(A)
CHLORIDE IONnon-polymer35.51Chemie (CL)
3C
(A)
waterwater18.022Chemie (HOH)
Sequence modifications
A: 187 - 378 (UniProt: Q9UH17)
PDBExternal DatabaseDetails
Met 186-initiating methionine
Ser 200Phe 200engineered mutation
Ser 228Trp 228engineered mutation
Lys 230Leu 230engineered mutation
Ser 250Ala 242engineered mutation
-Lys 243deletion
-Asn 244deletion
-Leu 245deletion
-Leu 246deletion
-Cys 247deletion
-Gly 248deletion
-Phe 249deletion
-Tyr 250deletion
Lys 308Phe 308engineered mutation
Asp 315Tyr 315engineered mutation
Gln 316Asp 316engineered mutation
Gly 317Pro 317engineered mutation
Arg 318Leu 318engineered mutation
Cys 319Tyr 319engineered mutation
Gln 320Lys 320engineered mutation
Leu 379-expression tag
Glu 380-expression tag
His 381-expression tag
His 382-expression tag
His 383-expression tag
His 384-expression tag
His 385-expression tag
His 386-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight22844.8
Non-Polymers*Number of molecules1
Total formula weight35.5
All*Total formula weight22880.3
*Water molecules are not included.

229183

PDB entries from 2024-12-18

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