6MXO

Structure of HPoleta incorporating dCTP opposite the 3-prime Pt(DACH)-GG

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA polymerase eta	polymer	442	49466.6	1	UniProt (Q9Y253) Pfam (PF00817) Pfam (PF21704) Pfam (PF11799)	Homo sapiens (Human)	RAD30 homolog A,Xeroderma pigmentosum variant type protein
2	B (T)	DNA (5'-D(*AP*CP*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3')	polymer	12	3607.4	1		Homo sapiens
3	C (P)	DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*AP*G)-3')	polymer	9	2810.9	1		Homo sapiens
4	D (A)	2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine	non-polymer		466.2	1	Chemie (0KX)
5	E, F (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	G, H, I (A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
7	J (T)	(cyclohex-1-ene-1,2-diamine)platinum(2+)	non-polymer		307.3	1	Chemie (9RD)
8	K, L (A, T)	water	water		18.0	110	Chemie (HOH)

Sequence modifications

A: 3 - 435 (UniProt: Q9Y253)

PDB	External Database	Details
Met -6	-	initiating methionine
Ala -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Gly 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	55884.8
Non-Polymers*	Number of molecules	7
	Total formula weight	1098.3
All*	Total formula weight	56983.1

*Water molecules are not included.