6MVY

NavAb voltage-gated sodium channel, residues 1-226, crystallized in the presence of Class 1B Anti-arrhythmic drug Lidocaine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ion transport protein	polymer	244	28202.6	2	UniProt (A8EVM5) Pfam (PF00520) Pfam (PF08016)	Arcobacter butzleri (strain RM4018)
2	C, D, E, F, H... (A, B)	1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		678.9	8	Chemie (PX4)
3	G, L (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	M, N (A, B)	water	water		18.0	39	Chemie (HOH)

Sequence modifications

A, B: 1001 - 1226 (UniProt: A8EVM5)

PDB	External Database	Details
Met 983	-	initiating methionine
Asp 984	-	expression tag
Tyr 985	-	expression tag
Lys 986	-	expression tag
Asp 987	-	expression tag
Asp 988	-	expression tag
Asp 989	-	expression tag
Asp 990	-	expression tag
Lys 991	-	expression tag
Gly 992	-	expression tag
Ser 993	-	expression tag
Leu 994	-	expression tag
Val 995	-	expression tag
Pro 996	-	expression tag
Arg 997	-	expression tag
Gly 998	-	expression tag
Ser 999	-	expression tag
His 1000	-	expression tag
Cys 1217	Ile 217	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	56405.2
Non-Polymers*	Number of molecules	10
	Total formula weight	5623.6
All*	Total formula weight	62028.8

*Water molecules are not included.