6MTI

Synaptotagmin-1 C2A, C2B domains and SNARE-pin proteins (5CCI) individually docked into Cryo-EM map of C2AB-SNARE complexes helically organized on lipid nanotube surface in presence of Mg2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (1, 6)	Synaptotagmin-1	polymer	127	14654.8	2	UniProt (P21707) Pfam (PF00168)	Rattus norvegicus (Rat)	Synaptotagmin I,SytI,p65
2	B, C, D, E (2, 3, 4, 5)	Synaptotagmin-1	polymer	281	32247.2	4	UniProt (P21707) Pfam (PF00168)	Rattus norvegicus (Rat)	Synaptotagmin I,SytI,p65
3	AA, G, K, O, S... (A, E, I, M, Q...)	Vesicle-associated membrane protein 2	polymer	63	7231.1	6	UniProt (P63045) Pfam (PF00957)	Rattus norvegicus (Rat)	VAMP-2,Synaptobrevin-2
4	BA, H, L, P, T... (B, F, J, N, R...)	Syntaxin-1A	polymer	67	7838.0	6	UniProt (P32851) Pfam (PF05739)	Rattus norvegicus (Rat)	Neuron-specific antigen HPC-1,Synaptotagmin-associated 35 kDa protein,P35A
5	CA, I, M, Q, U... (C, G, K, O, S...)	Synaptosomal-associated protein 25	polymer	77	9030.1	6	UniProt (P60881)	Rattus norvegicus (Rat)	SNAP-25,Super protein,SUP,Synaptosomal-associated 25 kDa protein
6	DA, J, N, R, V... (D, H, L, P, T...)	Synaptosomal-associated protein 25	polymer	65	7471.4	6	UniProt (P60881)	Rattus norvegicus (Rat)	SNAP-25,Super protein,SUP,Synaptosomal-associated 25 kDa protein
7	EA, FA, GA, HA, IA... (1, 2, 3, 4, 5...)	MAGNESIUM ION	non-polymer		24.3	10	Chemie (MG)

Sequence modifications

A, E, I, M, Q, U: 28 - 89 (UniProt: P63045)

PDB	External Database	Details
Gly 27	-	expression tag

B, F, J, N, R, V: 191 - 256 (UniProt: P32851)

PDB	External Database	Details
Met 190	-	initiating methionine

D, H, L, P, T, X: 141 - 204 (UniProt: P60881)

PDB	External Database	Details
Met 140	-	initiating methionine

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.