6MTI

Synaptotagmin-1 C2A, C2B domains and SNARE-pin proteins (5CCI) individually docked into Cryo-EM map of C2AB-SNARE complexes helically organized on lipid nanotube surface in presence of Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0016020	cellular_component	membrane
2	0016020	cellular_component	membrane
3	0016020	cellular_component	membrane
4	0016020	cellular_component	membrane
5	0016020	cellular_component	membrane
6	0016020	cellular_component	membrane
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
B	0005484	molecular_function	SNAP receptor activity
B	0006886	biological_process	intracellular protein transport
B	0016020	cellular_component	membrane
B	0016192	biological_process	vesicle-mediated transport
C	0000149	molecular_function	SNARE binding
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0017075	molecular_function	syntaxin-1 binding
E	0016020	cellular_component	membrane
E	0016192	biological_process	vesicle-mediated transport
F	0005484	molecular_function	SNAP receptor activity
F	0006886	biological_process	intracellular protein transport
F	0016020	cellular_component	membrane
F	0016192	biological_process	vesicle-mediated transport
G	0000149	molecular_function	SNARE binding
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0017075	molecular_function	syntaxin-1 binding
I	0016020	cellular_component	membrane
I	0016192	biological_process	vesicle-mediated transport
J	0005484	molecular_function	SNAP receptor activity
J	0006886	biological_process	intracellular protein transport
J	0016020	cellular_component	membrane
J	0016192	biological_process	vesicle-mediated transport
K	0000149	molecular_function	SNARE binding
K	0005249	molecular_function	voltage-gated potassium channel activity
K	0017075	molecular_function	syntaxin-1 binding
M	0016020	cellular_component	membrane
M	0016192	biological_process	vesicle-mediated transport
N	0005484	molecular_function	SNAP receptor activity
N	0006886	biological_process	intracellular protein transport
N	0016020	cellular_component	membrane
N	0016192	biological_process	vesicle-mediated transport
O	0000149	molecular_function	SNARE binding
O	0005249	molecular_function	voltage-gated potassium channel activity
O	0017075	molecular_function	syntaxin-1 binding
Q	0016020	cellular_component	membrane
Q	0016192	biological_process	vesicle-mediated transport
R	0005484	molecular_function	SNAP receptor activity
R	0006886	biological_process	intracellular protein transport
R	0016020	cellular_component	membrane
R	0016192	biological_process	vesicle-mediated transport
S	0000149	molecular_function	SNARE binding
S	0005249	molecular_function	voltage-gated potassium channel activity
S	0017075	molecular_function	syntaxin-1 binding
U	0016020	cellular_component	membrane
U	0016192	biological_process	vesicle-mediated transport
V	0005484	molecular_function	SNAP receptor activity
V	0006886	biological_process	intracellular protein transport
V	0016020	cellular_component	membrane
V	0016192	biological_process	vesicle-mediated transport
W	0000149	molecular_function	SNARE binding
W	0005249	molecular_function	voltage-gated potassium channel activity
W	0017075	molecular_function	syntaxin-1 binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG 1 301

Chain	Residue
1	ASP172
1	ASP178
1	PHE231
1	ASP232

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG 2 801

Chain	Residue
2	ASP172
2	ASP178
2	PHE231
2	ASP232

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG 2 802

Chain	Residue
2	ASP590
2	ASP644
2	TYR645
2	ASP646
2	ASP584

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG 3 801

Chain	Residue
3	ASP172
3	ASP178
3	PHE231
3	ASP232

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MG 3 802

Chain	Residue
3	ASP584
3	ASP590
3	ASP644
3	TYR645
3	ASP646

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG 4 801

Chain	Residue
4	ASP172
4	ASP178
4	PHE231
4	ASP232

---

site_id	AC7
Number of Residues	5
Details	binding site for residue MG 4 802

Chain	Residue
4	ASP584
4	ASP590
4	ASP644
4	TYR645
4	ASP646

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG 5 801

Chain	Residue
5	ASP172
5	ASP178
5	PHE231
5	ASP232

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MG 5 802

Chain	Residue
5	ASP584
5	ASP590
5	ASP644
5	TYR645
5	ASP646

---

site_id	AD1
Number of Residues	4
Details	binding site for residue MG 6 301

Chain	Residue
6	ASP172
6	ASP178
6	PHE231
6	ASP232

---

Functional Information from PROSITE/UniProt

site_id	PS00417
Number of Residues	20
Details	SYNAPTOBREVIN Synaptobrevin signature. NVDKVlERdqKLSeLdDRAD

Chain	Residue	Details
U	ASN49-ASP68

---

site_id	PS00914
Number of Residues	40
Details	SYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V

Chain	Residue	Details
V	ARG198-VAL237

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E) => ECO:0000269|PubMed:8243676, ECO:0000269|PubMed:8294407, ECO:0000305|PubMed:8103915

Chain	Residue	Details
D	ARG180
2	ASP584
2	ASP590
2	ASP644
2	ASP646
2	ASP652
3	LEU171
3	ASP172
3	ASP178
3	ASP230
3	PHE231
H	ARG180
3	ASP232
3	SER235
3	LYS236
3	ASP238
3	ASP584
3	ASP590
3	ASP644
3	ASP646
3	ASP652
4	LEU171
L	ARG180
4	ASP172
4	ASP178
4	ASP230
4	PHE231
4	ASP232
4	SER235
4	LYS236
4	ASP238
4	ASP584
4	ASP590
P	ARG180
4	ASP644
4	ASP646
4	ASP652
5	LEU171
5	ASP172
5	ASP178
5	ASP230
5	PHE231
5	ASP232
5	SER235
T	ARG180
5	LYS236
5	ASP238
5	ASP584
5	ASP590
5	ASP644
5	ASP646
5	ASP652
X	ARG180
2	SER235
2	LYS236
2	ASP238

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA) => ECO:0000269|PubMed:8243676, ECO:0000269|PubMed:8294407, ECO:0000305|PubMed:8103915

Chain	Residue	Details
D	GLN197
J	LYS253
J	LYS256
N	LYS252
N	LYS253
N	LYS256
R	LYS252
R	LYS253
H	GLN197
R	LYS256
V	LYS252
V	LYS253
V	LYS256
L	GLN197
P	GLN197
T	GLN197
X	GLN197
F	LYS253
F	LYS256
J	LYS252

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P60879

Chain	Residue	Details
D	SER154
H	SER154
L	SER154
P	SER154
T	SER154
X	SER154

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:12459461

Chain	Residue	Details
D	SER187
H	SER187
L	SER187
P	SER187
T	SER187
X	SER187
5	SER623
5	SER625

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	SITE: (Microbial infection) Cleavage; by C.botulinum neurotoxin type G (BoNT/G, botG) => ECO:0000269|PubMed:7910017

Chain	Residue	Details
A	ALA81
E	ALA81
I	ALA81
M	ALA81
Q	ALA81
U	ALA81

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