6MM6

Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 phosphorylation domain (2699-2904)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, E)	cAMP-dependent protein kinase catalytic subunit alpha	polymer	339	39598.2	2	UniProt (P05132) Pfam (PF00069)	Mus musculus (Mouse)	PKA C-alpha
2	C, D (F, D)	Ryanodine receptor 2	polymer	209	24257.6	2	UniProt (E9Q401) Pfam (PF02026)	Mus musculus (Mouse)	RyR2,Cardiac muscle ryanodine receptor,Cardiac muscle ryanodine receptor-calcium release channel,Type 2 ryanodine receptor
3	E (C)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
4	F, I (C, E)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
5	G (C)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
6	H, K, L (C, E, F)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
7	J (E)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
8	M, N, O, P (C, E, F, D)	water	water		18.0	365	Chemie (HOH)

Sequence modifications

C, E: 15 - 350 (UniProt: P05132)

PDB	External Database	Details
Ser 12	-	expression tag
Asn 13	-	expression tag
Ala 14	-	expression tag

F, D: 2699 - 2904 (UniProt: E9Q401)

PDB	External Database	Details
Ser 2696	-	expression tag
Asn 2697	-	expression tag
Ala 2698	-	expression tag
Ala 2879	Lys 2879	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	127711.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1390.0
All*	Total formula weight	129101.6

*Water molecules are not included.