Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MM6

Catalytic subunit of cAMP-dependent protein kinase A in complex with RyR2 phosphorylation domain (2699-2904)

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001669	cellular_component	acrosomal vesicle
C	0001707	biological_process	mesoderm formation
C	0001843	biological_process	neural tube closure
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004691	molecular_function	cAMP-dependent protein kinase activity
C	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0005930	cellular_component	axoneme
C	0005952	cellular_component	cAMP-dependent protein kinase complex
C	0006397	biological_process	mRNA processing
C	0006468	biological_process	protein phosphorylation
C	0006611	biological_process	protein export from nucleus
C	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
C	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016607	cellular_component	nuclear speck
C	0016740	molecular_function	transferase activity
C	0018105	biological_process	peptidyl-serine phosphorylation
C	0019901	molecular_function	protein kinase binding
C	0019904	molecular_function	protein domain specific binding
C	0021904	biological_process	dorsal/ventral neural tube patterning
C	0030007	biological_process	intracellular potassium ion homeostasis
C	0030145	molecular_function	manganese ion binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0031514	cellular_component	motile cilium
C	0031594	cellular_component	neuromuscular junction
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032024	biological_process	positive regulation of insulin secretion
C	0034237	molecular_function	protein kinase A regulatory subunit binding
C	0034605	biological_process	cellular response to heat
C	0036126	cellular_component	sperm flagellum
C	0042995	cellular_component	cell projection
C	0044853	cellular_component	plasma membrane raft
C	0045542	biological_process	positive regulation of cholesterol biosynthetic process
C	0045667	biological_process	regulation of osteoblast differentiation
C	0045722	biological_process	positive regulation of gluconeogenesis
C	0045879	biological_process	negative regulation of smoothened signaling pathway
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0048240	biological_process	sperm capacitation
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050766	biological_process	positive regulation of phagocytosis
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0051726	biological_process	regulation of cell cycle
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0070417	biological_process	cellular response to cold
C	0070613	biological_process	regulation of protein processing
C	0071333	biological_process	cellular response to glucose stimulus
C	0071374	biological_process	cellular response to parathyroid hormone stimulus
C	0071377	biological_process	cellular response to glucagon stimulus
C	0097546	cellular_component	ciliary base
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
C	0106310	molecular_function	protein serine kinase activity
C	0141156	biological_process	cAMP/PKA signal transduction
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
C	1990044	biological_process	protein localization to lipid droplet
C	2000810	biological_process	regulation of bicellular tight junction assembly
D	0006816	biological_process	calcium ion transport
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001669	cellular_component	acrosomal vesicle
E	0001707	biological_process	mesoderm formation
E	0001843	biological_process	neural tube closure
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004691	molecular_function	cAMP-dependent protein kinase activity
E	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0005930	cellular_component	axoneme
E	0005952	cellular_component	cAMP-dependent protein kinase complex
E	0006397	biological_process	mRNA processing
E	0006468	biological_process	protein phosphorylation
E	0006611	biological_process	protein export from nucleus
E	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
E	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016607	cellular_component	nuclear speck
E	0016740	molecular_function	transferase activity
E	0018105	biological_process	peptidyl-serine phosphorylation
E	0019901	molecular_function	protein kinase binding
E	0019904	molecular_function	protein domain specific binding
E	0021904	biological_process	dorsal/ventral neural tube patterning
E	0030007	biological_process	intracellular potassium ion homeostasis
E	0030145	molecular_function	manganese ion binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0031514	cellular_component	motile cilium
E	0031594	cellular_component	neuromuscular junction
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032024	biological_process	positive regulation of insulin secretion
E	0034237	molecular_function	protein kinase A regulatory subunit binding
E	0034605	biological_process	cellular response to heat
E	0036126	cellular_component	sperm flagellum
E	0042995	cellular_component	cell projection
E	0044853	cellular_component	plasma membrane raft
E	0045542	biological_process	positive regulation of cholesterol biosynthetic process
E	0045667	biological_process	regulation of osteoblast differentiation
E	0045722	biological_process	positive regulation of gluconeogenesis
E	0045879	biological_process	negative regulation of smoothened signaling pathway
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0048240	biological_process	sperm capacitation
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050766	biological_process	positive regulation of phagocytosis
E	0050804	biological_process	modulation of chemical synaptic transmission
E	0051726	biological_process	regulation of cell cycle
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070417	biological_process	cellular response to cold
E	0070613	biological_process	regulation of protein processing
E	0071333	biological_process	cellular response to glucose stimulus
E	0071374	biological_process	cellular response to parathyroid hormone stimulus
E	0071377	biological_process	cellular response to glucagon stimulus
E	0097546	cellular_component	ciliary base
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
E	0106310	molecular_function	protein serine kinase activity
E	0141156	biological_process	cAMP/PKA signal transduction
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
E	1990044	biological_process	protein localization to lipid droplet
E	2000810	biological_process	regulation of bicellular tight junction assembly
F	0006816	biological_process	calcium ion transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ACT C 401

Chain	Residue
C	TYR235
C	PHE239
D	ALA2798
D	TYR2800

site_id	AC2
Number of Residues	13
Details	binding site for residue ANP C 402

Chain	Residue
C	LYS72
C	GLU121
C	TYR122
C	VAL123
C	GLU127
C	HOH534
C	HOH588
D	ARG2804
C	THR51
C	GLY52
C	SER53
C	VAL57
C	ALA70

site_id	AC3
Number of Residues	7
Details	binding site for residue PGE C 403

Chain	Residue
C	GLU155
C	HIS158
C	SER159
C	LYS217
C	TRP221
C	GLY282
C	HOH538

site_id	AC4
Number of Residues	2
Details	binding site for residue CL C 404

Chain	Residue
C	GLY200
D	GLN2808

site_id	AC5
Number of Residues	14
Details	binding site for residue ANP E 401

Chain	Residue
E	LEU49
E	THR51
E	GLY52
E	SER53
E	VAL57
E	ALA70
E	LYS72
E	GLU121
E	TYR122
E	VAL123
E	ASP184
E	HOH514
E	HOH516
E	HOH574

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO E 402

Chain	Residue
E	LYS72
E	GLU91
E	LEU95
E	MET118
E	MET120
E	THR183

site_id	AC7
Number of Residues	3
Details	binding site for residue CL E 403

Chain	Residue
D	TRP2786
D	ARG2904
E	GLU140

site_id	AC8
Number of Residues	4
Details	binding site for residue CL F 3001

Chain	Residue
C	GLU140
F	TRP2786
F	MET2842
F	ARG2904

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK

Chain	Residue	Details
C	LEU49-LYS72

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI

Chain	Residue	Details
C	LEU162-ILE174

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21183079

Chain	Residue	Details
F	SER2796
F	SER2810
D	SER2796
D	SER2810

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CaMK2D and PKA => ECO:0000269\|PubMed:20431056, ECO:0000269\|PubMed:21098440, ECO:0007744\|PubMed:21183079

Chain	Residue	Details
F	SER2807
D	SER2807
C	GLU121
C	LYS168
E	LEU49
E	LYS72
E	GLU121
E	LYS168

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CaMK2D => ECO:0000269\|PubMed:21098440, ECO:0007744\|PubMed:21183079

Chain	Residue	Details
F	SER2813
D	SER2813
E	THR48
E	THR195

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:22323819, ECO:0000305\|PubMed:8395513

Chain	Residue	Details
C	SER139
E	SER139

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269\|PubMed:22323819, ECO:0000269\|PubMed:8395513, ECO:0000269\|PubMed:9707564

Chain	Residue	Details
C	TPO197
E	TPO197

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:21866565

Chain	Residue	Details
C	TYR330
E	TYR330

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000305\|PubMed:8395513

Chain	Residue	Details
C	SEP338
E	SEP338

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)