6MLB
Crystal structure of the holo retinal-bound domain-swapped dimer Q108K:K40L:T51F mutant of human cellular retinol binding protein II
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Retinol-binding protein 2 | polymer | 133 | 15628.6 | 4 | UniProt (P50120) Pfam (PF00061) | Homo sapiens (Human) | Cellular retinol-binding protein II,CRBP-II |
| 2 | E, H, M, N (B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) PubChem (753) | |||
| 3 | F, G, J, K, L (C, D) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) PubChem (175) | |||
| 4 | I, O (C, D) | RETINAL | non-polymer | 284.4 | 2 | Chemie (RET) PubChem (1070) PubChem (638015) PubChem (5353924) PubChem (6436079) PubChem (6436082) PubChem (11426127) PubChem (12227253) PubChem (12227254) PubChem (12227256) PubChem (12227257) PubChem (12227258) PubChem (12227259) PubChem (12227269) PubChem (12227270) PubChem (12227271) PubChem (23254473) PubChem (177675058) PubChem (5280490) PubChem (5381765) PubChem (87082476) PubChem (87110449) PubChem (87110609) PubChem (88398773) PubChem (88407543) PubChem (134688327) PubChem (140510408) PubChem (145826762) PubChem (169423542) PubChem (172878320) | |||
| 5 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 133 (UniProt: P50120)
| PDB | External Database | Details |
|---|---|---|
| Leu 40 | Lys 41 | engineered mutation |
| Phe 51 | Thr 52 | engineered mutation |
| Lys 108 | Gln 109 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62514.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1232.5 | |
| All* | Total formula weight | 63746.7 |
