6MLB

Crystal structure of the holo retinal-bound domain-swapped dimer Q108K:K40L:T51F mutant of human cellular retinol binding protein II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005501	molecular_function	retinoid binding
A	0005504	molecular_function	fatty acid binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006776	biological_process	vitamin A metabolic process
A	0008289	molecular_function	lipid binding
A	0008544	biological_process	epidermis development
A	0015908	biological_process	fatty acid transport
A	0016918	molecular_function	retinal binding
A	0019841	molecular_function	retinol binding
B	0005501	molecular_function	retinoid binding
B	0005504	molecular_function	fatty acid binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006776	biological_process	vitamin A metabolic process
B	0008289	molecular_function	lipid binding
B	0008544	biological_process	epidermis development
B	0015908	biological_process	fatty acid transport
B	0016918	molecular_function	retinal binding
B	0019841	molecular_function	retinol binding
C	0005501	molecular_function	retinoid binding
C	0005504	molecular_function	fatty acid binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006776	biological_process	vitamin A metabolic process
C	0008289	molecular_function	lipid binding
C	0008544	biological_process	epidermis development
C	0015908	biological_process	fatty acid transport
C	0016918	molecular_function	retinal binding
C	0019841	molecular_function	retinol binding
D	0005501	molecular_function	retinoid binding
D	0005504	molecular_function	fatty acid binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006776	biological_process	vitamin A metabolic process
D	0008289	molecular_function	lipid binding
D	0008544	biological_process	epidermis development
D	0015908	biological_process	fatty acid transport
D	0016918	molecular_function	retinal binding
D	0019841	molecular_function	retinol binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue GOL B 201

Chain	Residue
B	ASP91
B	ILE110
D	THR1

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site_id	AC2
Number of Residues	4
Details	binding site for residue ACT C 201

Chain	Residue
A	TYR19
C	GLN97
C	ARG104
C	GLY105

---

site_id	AC3
Number of Residues	6
Details	binding site for residue ACT C 202

Chain	Residue
C	ASN103
C	TRP106
C	LYS107
C	THR120
C	CYS95
C	VAL96

---

site_id	AC4
Number of Residues	2
Details	binding site for residue GOL C 203

Chain	Residue
C	ASP63
C	ASP71

---

site_id	AC5
Number of Residues	3
Details	binding site for residue ACT D 201

Chain	Residue
D	CYS95
D	TRP106
D	THR120

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ACT D 202

Chain	Residue
C	ASP26
C	ALA28
C	THR29
D	GLU89
D	LYS107

---

site_id	AC7
Number of Residues	1
Details	binding site for residue ACT D 203

Chain	Residue
D	HOH322

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL D 204

Chain	Residue
B	HIS81
D	VAL66
D	THR87
D	TRP88
D	HOH323

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL D 205

Chain	Residue
D	ASP61
D	VAL62
D	ASP63
D	GLU72
D	TYR73

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Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GTWeMesNeNFEgYMKAL

Chain	Residue	Details
A	GLY6-LEU23

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:18076076

Chain	Residue	Details
A	LEU40
A	LYS108
B	LEU40
B	LYS108
C	LEU40
C	LYS108
D	LEU40
D	LYS108

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