6LN2

Crystal structure of full length human GLP1 receptor in complex with Fab fragment (Fab7F38)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glucagon-like peptide 1 receptor,Rubredoxin,Glucagon-like peptide 1 receptor	polymer	469	54620.0	1	UniProt (P43220) UniProt (P00268) Pfam (PF02793) Pfam (PF00002) Pfam (PF00301)	Homo sapiens (Human)	GLP-1R,Rd,GLP-1R
2	B (B)	Fab7F38_light chain	polymer	213	23307.9	1		Mus musculus
3	C (C)	Fab7F38_heavy chain	polymer	226	24476.3	1		Mus musculus
4	D (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	E (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
6	F (A)	N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine	non-polymer		515.5	1	Chemie (97Y)

Sequence modifications

A: 24 - 260 (UniProt: P43220)

PDB	External Database	Details
Cys 193	Ser 193	engineered mutation
Phe 196	Ile 196	engineered mutation
Ala 225	Ser 225	engineered mutation
Cys 233	Met 233	engineered mutation

A: 1001 - 1054 (UniProt: P00268)
A: 262 - 439 (UniProt: P43220)

PDB	External Database	Details
Ala 271	Ser 271	engineered mutation
Cys 317	Ile 317	engineered mutation
Ile 318	Gly 318	engineered mutation
Ala 346	Lys 346	engineered mutation
Phe 347	Cys 347	engineered mutation
Cys 361	Gly 361	engineered mutation
Asp 387	Glu 387	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	102404.2
Non-Polymers*	Number of molecules	3
	Total formula weight	802.1
All*	Total formula weight	103206.3

*Water molecules are not included.