6LN2
Crystal structure of full length human GLP1 receptor in complex with Fab fragment (Fab7F38)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004967 | molecular_function | glucagon receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0008528 | molecular_function | G protein-coupled peptide receptor activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0043448 | biological_process | alkane catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00202 |
| Number of Residues | 11 |
| Details | RUBREDOXIN Rubredoxin signature. IpDDWvCPlCG |
| Chain | Residue | Details |
| A | ILE1033-GLY1043 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH |
| Chain | Residue | Details |
| C | TYR206-HIS212 | |
| B | TYR191-HIS197 |
| site_id | PS00649 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDeya.CWpdGepgsfvnvsCP |
| Chain | Residue | Details |
| A | CYS62-PRO86 |
| site_id | PS00650 |
| Number of Residues | 16 |
| Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLMVaILYCFvNneV |
| Chain | Residue | Details |
| A | GLN394-VAL409 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 166 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | ARG24-GLU139 | |
| A | LYS202-ARG227 | |
| A | TYR291-TYR305 | |
| A | MET371-LYS383 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | GLN140-ALA164 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 29 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | ILE165-THR175 | |
| A | CYS329-ARG348 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | ARG176-LEU201 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | LEU228-LEU251 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | PHE266-LEU290 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | TRP306-ILE328 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | LEU349-VAL370 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:28514449 |
| Chain | Residue | Details |
| A | LEU384-PHE404 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | SITE: Interaction with the endogenous ligand GLP-1 => ECO:0000269|PubMed:19861722 |
| Chain | Residue | Details |
| A | ARG121 | |
| A | GLU128 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylcysteine => ECO:0000269|PubMed:21901419 |
| Chain | Residue | Details |
| A | CYS341 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylarginine => ECO:0000269|PubMed:21901419 |
| Chain | Residue | Details |
| A | ARG348 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906 |
| Chain | Residue | Details |
| A | ASN63 | |
| A | ASN82 | |
| A | ASN115 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00241, ECO:0000269|PubMed:10216292 |
| Chain | Residue | Details |
| A | CYS1006 | |
| A | CYS1009 | |
| A | CYS1039 | |
| A | CYS1042 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: N-formylmethionine => ECO:0000269|PubMed:1637309 |
| Chain | Residue | Details |
| A | MET1001 |
