6L4O
Crystal structure of API5-FGF2 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Apoptosis inhibitor 5 | polymer | 544 | 61250.8 | 1 | UniProt (Q9BZZ5) Pfam (PF05918) | Homo sapiens (Human) | API-5,Antiapoptosis clone 11 protein,AAC-11,Cell migration-inducing gene 8 protein,Fibroblast growth factor 2-interacting factor,FIF,Protein XAGL |
| 2 | B (B) | Fibroblast growth factor 2 | polymer | 176 | 19715.4 | 1 | UniProt (P09038) Pfam (PF00167) | Homo sapiens (Human) | FGF-2,Basic fibroblast growth factor,bFGF,Heparin-binding growth factor 2,HBGF-2 |
| 3 | C, D (A, B) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 1 - 524 (UniProt: Q9BZZ5)
B: 135 - 288 (UniProt: P09038)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 113 | - | expression tag |
| His 114 | - | expression tag |
| His 115 | - | expression tag |
| His 116 | - | expression tag |
| His 117 | - | expression tag |
| His 118 | - | expression tag |
| His 119 | - | expression tag |
| Gly 120 | - | expression tag |
| Ser 121 | - | expression tag |
| Leu 122 | - | expression tag |
| Val 123 | - | expression tag |
| Pro 124 | - | expression tag |
| Arg 125 | - | expression tag |
| Ser 126 | - | expression tag |
| Glu 127 | - | expression tag |
| Asn 128 | - | expression tag |
| Leu 129 | - | expression tag |
| Tyr 130 | - | expression tag |
| Phe 131 | - | expression tag |
| Gln 132 | - | expression tag |
| Gly 133 | - | expression tag |
| Ser 134 | - | expression tag |
| Ser 211 | Cys 211 | engineered mutation |
| Ser 229 | Cys 229 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80966.2 | |
| All* | Total formula weight | 80966.2 |
