6L4O

Crystal structure of API5-FGF2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Apoptosis inhibitor 5	polymer	544	61250.8	1	UniProt (Q9BZZ5) Pfam (PF05918)	Homo sapiens (Human)	API-5,Antiapoptosis clone 11 protein,AAC-11,Cell migration-inducing gene 8 protein,Fibroblast growth factor 2-interacting factor,FIF,Protein XAGL
2	B (B)	Fibroblast growth factor 2	polymer	176	19715.4	1	UniProt (P09038) Pfam (PF00167)	Homo sapiens (Human)	FGF-2,Basic fibroblast growth factor,bFGF,Heparin-binding growth factor 2,HBGF-2
3	C, D (A, B)	water	water		18.0	35	Chemie (HOH)

Sequence modifications

A: 1 - 524 (UniProt: Q9BZZ5)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

B: 135 - 288 (UniProt: P09038)

PDB	External Database	Details
Met 113	-	expression tag
His 114	-	expression tag
His 115	-	expression tag
His 116	-	expression tag
His 117	-	expression tag
His 118	-	expression tag
His 119	-	expression tag
Gly 120	-	expression tag
Ser 121	-	expression tag
Leu 122	-	expression tag
Val 123	-	expression tag
Pro 124	-	expression tag
Arg 125	-	expression tag
Ser 126	-	expression tag
Glu 127	-	expression tag
Asn 128	-	expression tag
Leu 129	-	expression tag
Tyr 130	-	expression tag
Phe 131	-	expression tag
Gln 132	-	expression tag
Gly 133	-	expression tag
Ser 134	-	expression tag
Ser 211	Cys 211	engineered mutation
Ser 229	Cys 229	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80966.2
All*	Total formula weight	80966.2

*Water molecules are not included.