6L4O

Crystal structure of API5-FGF2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005737	cellular_component	cytoplasm
A	0006915	biological_process	apoptotic process
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0017134	molecular_function	fibroblast growth factor binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0044346	biological_process	fibroblast apoptotic process
A	2000270	biological_process	negative regulation of fibroblast apoptotic process
B	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00247
Number of Residues	24
Details	HBGF_FGF HBGF/FGF family signature. GrLlAsksvtd.ECfFfErlesnnY

Chain	Residue	Details
B	GLY222-TYR245

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
B	ASN169

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Important for interaction with integrin => ECO:0000269|PubMed:28302677

Chain	Residue	Details
B	LYS261
B	ARG262
B	LYS267

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by TEC => ECO:0000269|PubMed:20230531

Chain	Residue	Details
B	TYR215

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211

Chain	Residue	Details
B	LYS228

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35841

Chain	Residue	Details
A	SER469

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
A	ARG500

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