6KYH
Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | SH3 and multiple ankyrin repeat domains protein 3 | polymer | 361 | 40254.5 | 4 | UniProt (Q4ACU6) Pfam (PF12796) In PDB | Mus musculus (Mouse) | Shank3,Proline-rich synapse-associated protein 2,ProSAP2,SPANK-2 |
2 | F, G, H, E | GTPase HRas | polymer | 171 | 19302.7 | 4 | UniProt (Q61411) Pfam (PF00071) In PDB | Mus musculus (Mouse) | H-Ras-1,Transforming protein p21,c-H-ras,p21ras |
3 | F, G, H, E | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 4 | Chemie (GNP) | |||
4 | F, G, H, E | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) |
Sequence modifications
A, B, C, D: 8 - 362 (UniProt: Q4ACU6)
F, G, H, E: 1 - 167 (UniProt: Q61411)
PDB | External Database | Details |
---|---|---|
Gly 2 | - | expression tag |
Pro 3 | - | expression tag |
Gly 4 | - | expression tag |
Ser 5 | - | expression tag |
Glu 6 | - | expression tag |
Phe 7 | - | expression tag |
Lys 42 | Ala 42 | engineered mutation |
Arg 231 | Leu 231 | engineered mutation |
Tyr 304 | Phe 304 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Pro -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 238228.7 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2186.0 | |
All* | Total formula weight | 240414.7 |