6KYH

Crystal structure of Shank3 NTD-ANK A42K mutant in complex with HRas

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
E	0007165	biological_process	signal transduction
E	0016020	cellular_component	membrane
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
H	0003924	molecular_function	GTPase activity
H	0005525	molecular_function	GTP binding
H	0007165	biological_process	signal transduction
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue GNP F 201

Chain	Residue
F	GLY13
F	GLU31
F	TYR32
F	PRO34
F	THR35
F	ALA59
F	GLY60
F	ASN116
F	LYS117
F	ASP119
F	LEU120
F	VAL14
F	ALA146
F	LYS147
F	MG202
F	GLY15
F	LYS16
F	SER17
F	ALA18
F	PHE28
F	VAL29
F	ASP30

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG F 202

Chain	Residue
F	SER17
F	THR35
F	ASP57
F	GNP201

---

site_id	AC3
Number of Residues	20
Details	binding site for residue GNP G 201

Chain	Residue
G	GLY13
G	VAL14
G	GLY15
G	LYS16
G	SER17
G	ALA18
G	ASP30
G	TYR32
G	PRO34
G	THR35
G	ALA59
G	GLY60
G	GLN61
G	ASN116
G	LYS117
G	ASP119
G	SER145
G	ALA146
G	LYS147
G	MG202

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG G 202

Chain	Residue
G	SER17
G	THR35
G	ASP57
G	GNP201

---

site_id	AC5
Number of Residues	21
Details	binding site for residue GNP H 201

Chain	Residue
H	GLY13
H	VAL14
H	GLY15
H	LYS16
H	SER17
H	ALA18
H	ASP30
H	GLU31
H	TYR32
H	PRO34
H	THR35
H	ALA59
H	GLY60
H	GLN61
H	ASN116
H	LYS117
H	ASP119
H	LEU120
H	SER145
H	ALA146
H	MG202

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MG H 202

Chain	Residue
H	LYS16
H	SER17
H	THR35
H	ASP57
H	GNP201

---

site_id	AC7
Number of Residues	18
Details	binding site for residue GNP E 201

Chain	Residue
E	GLY13
E	GLY15
E	LYS16
E	SER17
E	ALA18
E	VAL29
E	ASP30
E	GLU31
E	TYR32
E	PRO34
E	THR35
E	GLY60
E	GLN61
E	ASN116
E	ASP119
E	LEU120
E	ALA146
E	MG202

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG E 202

Chain	Residue
E	SER17
E	THR35
E	ASP57
E	GNP201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
G	GLY10
F	GLY10
F	ASP57
F	ASN116
G	ASP57
G	ASN116
H	GLY10
H	ASP57
H	ASN116
E	GLY10
E	ASP57
E	ASN116

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P01112

Chain	Residue	Details
F	MET1
G	MET1
H	MET1
E	MET1

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000250|UniProtKB:P01112

Chain	Residue	Details
F	THR2
G	THR2
H	THR2
E	THR2

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P01112

Chain	Residue	Details
F	CYS118
G	CYS118
H	CYS118
E	CYS118

---