6KTR

Crystal structure of fibroblast growth factor 19 in complex with Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, F)	G1A8-Fab-HC	polymer	233	24876.7	2		Homo sapiens (Human)
2	B, F (B, G)	G1A8-Fab-LC	polymer	216	22715.9	2		Homo sapiens (Human)
3	C, D (C, D)	Fibroblast growth factor 19	polymer	218	24556.8	2	UniProt (O95750) Pfam (PF00167)	Homo sapiens (Human)	FGF-19
4	G, H, I, J, K... (B, C, D, G)	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
5	P, Q, S (F, G)	SODIUM ION	non-polymer		23.0	3	Chemie (NA)
6	T, U, V, W, X... (A, B, C, D, F...)	water	water		18.0	265	Chemie (HOH)

Sequence modifications

C, D: 23 - 216 (UniProt: O95750)

PDB	External Database	Details
Ser 217	-	expression tag
Gly 218	-	expression tag
Gly 219	-	expression tag
Gly 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
Leu 227	-	expression tag
Asn 228	-	expression tag
Asp 229	-	expression tag
Ile 230	-	expression tag
Phe 231	-	expression tag
Glu 232	-	expression tag
Ala 233	-	expression tag
Gln 234	-	expression tag
Lys 235	-	expression tag
Ile 236	-	expression tag
Glu 237	-	expression tag
Trp 238	-	expression tag
His 239	-	expression tag
Glu 240	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	144298.9
Non-Polymers*	Number of molecules	13
	Total formula weight	1029.6
All*	Total formula weight	145328.5

*Water molecules are not included.