6KRZ

Crystal structure of the human adiponectin receptor 1 D208A mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Adiponectin receptor protein 1	polymer	305	34996.8	3	UniProt (Q96A54) Pfam (PF03006)	Homo sapiens (Human)	Progestin and adipoQ receptor family member 1,Progestin and adipoQ receptor family member I
2	D, F, H (D, F, H)	The heavy chain variable domain (Antibody)	polymer	119	13160.6	3		Mus musculus
3	E, G, I (E, G, I)	The light chain variable domain (Antibody)	polymer	107	11647.9	3		Mus musculus
4	J, N, P (A, B, C)	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)
5	K, L (A)	OLEIC ACID	non-polymer		282.5	2	Chemie (OLA)
6	M, O, Q (A, B, C)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
7	R, S (C)	(2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	2	Chemie (OLB)
8	AA, BA, T, U, V... (H, I, A, B, C...)	water	water		18.0	89	Chemie (HOH)

Sequence modifications

A, B, C: 89 - 375 (UniProt: Q96A54)

PDB	External Database	Details
Met -17	-	initiating methionine
Asp -16	-	expression tag
Tyr -15	-	expression tag
Lys -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Lys -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 208	Asp 208	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	179415.8
Non-Polymers*	Number of molecules	10
	Total formula weight	1759.1
All*	Total formula weight	181175.0

*Water molecules are not included.