6KO5
Complex structure of Ghrelin receptor with Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Chimera of Soluble cytochrome b562 and Growth hormone secretagogue receptor type 1 | polymer | 424 | 47889.0 | 1 | UniProt (P0ABE7) UniProt (Q92847) Pfam (PF07361) Pfam (PF00001) | Escherichia coli | Cytochrome b-562,GHS-R,GH-releasing peptide receptor,GHRP,Ghrelin receptor |
| 2 | B (H) | Fab7881 Heavy Chain | polymer | 218 | 23332.0 | 1 | Mus musculus | ||
| 3 | C (L) | Fab7881 Light Chain | polymer | 219 | 24279.0 | 1 | Mus musculus | ||
| 4 | D (A) | 6-(4-bromanyl-2-fluoranyl-phenoxy)-2-methyl-3-[[(3~{S})-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one | non-polymer | 489.4 | 1 | Chemie (8QX) |
Sequence modifications
A: 1001 - 1106 (UniProt: P0ABE7)
A: null - 346 (UniProt: Q92847)
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Lys 130 | Thr 130 | engineered mutation |
| Gln 188 | Asn 188 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 95499.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 489.4 | |
| All* | Total formula weight | 95989.3 |
