6KMS

Crystal structure of human N6amt1-Trm112 in complex with SAM (space group I422)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (C, D)	Methyltransferase N6AMT1	polymer	228	24878.4	2	UniProt (Q9Y5N5) Pfam (PF05175)	Homo sapiens (Human)	HemK methyltransferase family member 2,M.HsaHemK2P,Methylarsonite methyltransferase N6AMT1,N(6)-adenine-specific DNA methyltransferase 1,Protein N(5)-glutamine methyltransferase
2	B, C (A, B)	Multifunctional methyltransferase subunit TRM112-like protein	polymer	126	14627.9	2	UniProt (Q9UI30) Pfam (PF03966)	Homo sapiens (Human)	tRNA methyltransferase 112 homolog
3	E, F (C, D)	S-ADENOSYLMETHIONINE	non-polymer		398.4	2	Chemie (SAM)

Sequence modifications

C, D: 1 - 214 (UniProt: Q9Y5N5)

PDB	External Database	Details
Mse -13	-	expression tag
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag

A, B: 1 - 125 (UniProt: Q9UI30)

PDB	External Database	Details
Mse 0	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	79012.7
Non-Polymers*	Number of molecules	2
	Total formula weight	796.9
All*	Total formula weight	79809.6

*Water molecules are not included.