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6KMS

Crystal structure of human N6amt1-Trm112 in complex with SAM (space group I422)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000470biological_processmaturation of LSU-rRNA
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006364biological_processrRNA processing
A0008276molecular_functionprotein methyltransferase activity
A0018364biological_processpeptidyl-glutamine methylation
A0030488biological_processtRNA methylation
A0030490biological_processmaturation of SSU-rRNA
A0031167biological_processrRNA methylation
A0032991cellular_componentprotein-containing complex
A0043528cellular_componenttRNA (m2G10) methyltransferase complex
A0045815biological_processtranscription initiation-coupled chromatin remodeling
A0046982molecular_functionprotein heterodimerization activity
A0048471cellular_componentperinuclear region of cytoplasm
A0070476biological_processrRNA (guanine-N7)-methylation
A0141106molecular_functiontRNA methyltransferase activator activity
A2000234biological_processpositive regulation of rRNA processing
B0000470biological_processmaturation of LSU-rRNA
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006364biological_processrRNA processing
B0008276molecular_functionprotein methyltransferase activity
B0018364biological_processpeptidyl-glutamine methylation
B0030488biological_processtRNA methylation
B0030490biological_processmaturation of SSU-rRNA
B0031167biological_processrRNA methylation
B0032991cellular_componentprotein-containing complex
B0043528cellular_componenttRNA (m2G10) methyltransferase complex
B0045815biological_processtranscription initiation-coupled chromatin remodeling
B0046982molecular_functionprotein heterodimerization activity
B0048471cellular_componentperinuclear region of cytoplasm
B0070476biological_processrRNA (guanine-N7)-methylation
B0141106molecular_functiontRNA methyltransferase activator activity
B2000234biological_processpositive regulation of rRNA processing
C0003676molecular_functionnucleic acid binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005829cellular_componentcytosol
C0006325biological_processchromatin organization
C0008168molecular_functionmethyltransferase activity
C0008276molecular_functionprotein methyltransferase activity
C0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
C0009007molecular_functionsite-specific DNA-methyltransferase (adenine-specific) activity
C0009404biological_processtoxin metabolic process
C0016740molecular_functiontransferase activity
C0018364biological_processpeptidyl-glutamine methylation
C0018872biological_processarsonoacetate metabolic process
C0030307biological_processpositive regulation of cell growth
C0030791molecular_functionarsenite methyltransferase activity
C0032259biological_processmethylation
C0032775biological_processobsolete DNA methylation on adenine
C0032991cellular_componentprotein-containing complex
C0035657cellular_componenteRF1 methyltransferase complex
C0036009molecular_functionprotein-glutamine N-methyltransferase activity
C0042054molecular_functionhistone methyltransferase activity
C0045814biological_processnegative regulation of gene expression, epigenetic
C0045815biological_processtranscription initiation-coupled chromatin remodeling
C0140984molecular_functionhistone H4K12 methyltransferase activity
C1904047molecular_functionS-adenosyl-L-methionine binding
D0003676molecular_functionnucleic acid binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005829cellular_componentcytosol
D0006325biological_processchromatin organization
D0008168molecular_functionmethyltransferase activity
D0008276molecular_functionprotein methyltransferase activity
D0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
D0009007molecular_functionsite-specific DNA-methyltransferase (adenine-specific) activity
D0009404biological_processtoxin metabolic process
D0016740molecular_functiontransferase activity
D0018364biological_processpeptidyl-glutamine methylation
D0018872biological_processarsonoacetate metabolic process
D0030307biological_processpositive regulation of cell growth
D0030791molecular_functionarsenite methyltransferase activity
D0032259biological_processmethylation
D0032775biological_processobsolete DNA methylation on adenine
D0032991cellular_componentprotein-containing complex
D0035657cellular_componenteRF1 methyltransferase complex
D0036009molecular_functionprotein-glutamine N-methyltransferase activity
D0042054molecular_functionhistone methyltransferase activity
D0045814biological_processnegative regulation of gene expression, epigenetic
D0045815biological_processtranscription initiation-coupled chromatin remodeling
D0140984molecular_functionhistone H4K12 methyltransferase activity
D1904047molecular_functionS-adenosyl-L-methionine binding
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue SAM C 301
ChainResidue
CTYR23
CASP103
CLEU104
CASN122
CPRO124
CALA140
CALA141
CTHR29
CGLU51
CGLY53
CSER54
CGLY55
CSER56
CASP77
CILE78

site_idAC2
Number of Residues13
Detailsbinding site for residue SAM D 301
ChainResidue
DTYR23
DTHR29
DGLU51
DGLY53
DGLY55
DVAL59
DASP77
DILE78
DLEU104
DASN122
DALA140
DALA141
DARG154

Functional Information from PROSITE/UniProt
site_idPS00092
Number of Residues7
DetailsN6_MTASE N-6 Adenine-specific DNA methylases signature. LVFNPPY
ChainResidueDetails
CLEU119-TYR125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER119
DASP103
DLEU104
DASN122
BSER119
CASP77
CASP103
CLEU104
CASN122
DTHR29
DGLU51
DASP77

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER125
BSER125

237735

PDB entries from 2025-06-18

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