6KDJ
HIV-1 reverse transcriptase with Q151M/Y115F/F116Y:DNA:lamivudine 5'-triphosphate ternary complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | HIV-1 reverse transcriptase p66 subunit | polymer | 557 | 64033.4 | 2 | UniProt (D3XFN5) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) UniProt (by SIFTS) (P12497) In PDB | Human immunodeficiency virus 1 | |
2 | B, D | HIV-1 RT p51 subunit | polymer | 444 | 51861.5 | 2 | UniProt (P12497) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 | HIV-1 reverse transcriptase p51 subunit, p51 RT |
3 | E, F | DNA/RNA (38-MER) | polymer | 38 | 11764.5 | 2 | synthetic construct | ||
4 | G | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900003) | sucrose | ||
5 | A, C | Lamivudine Triphosphate | non-polymer | 469.2 | 2 | Chemie (1RZ) | |||
6 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
7 | B, D | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
8 | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 555 (UniProt: D3XFN5)
B, D: 1 - 428 (UniProt: P12497)
PDB | External Database | Details |
---|---|---|
Met -1 | - | expression tag |
Val 0 | - | expression tag |
Phe 115 | Tyr 214 | engineered mutation |
Tyr 116 | Phe 215 | engineered mutation |
Met 151 | Gln 250 | engineered mutation |
Ser 162 | Cys 261 | engineered mutation |
Ser 280 | Cys 379 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -15 | - | expression tag |
Ala -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
Ala -7 | - | expression tag |
Leu -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Leu -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 162 | Cys 749 | engineered mutation |
Ser 280 | Cys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 255318.9 | |
Branched | Number of molecules | 1 |
Total formula weight | 342.3 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1355.4 | |
All* | Total formula weight | 257016.6 |