6JOL
Crystal structure of PDGFRA in complex with imatinib by co-crystallization
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Platelet-derived growth factor receptor alpha | polymer | 356 | 40588.7 | 1 | UniProt (P16234) Pfam (PF07714) In PDB | Homo sapiens (Human) | PDGFR-alpha,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a antigen,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2,PDGFR-2 |
| 2 | A | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | non-polymer | 493.6 | 1 | Chemie (STI) | |||
| 3 | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A: 550 - 768 (UniProt: P16234)
A: 769 - 973 (UniProt: P16234)
| PDB | External Database | Details |
|---|---|---|
| Gly 546 | - | expression tag |
| Ala 547 | - | expression tag |
| Met 548 | - | expression tag |
| Asp 549 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40588.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 493.6 | |
| All* | Total formula weight | 41082.3 |
