6JOJ
Crystal structure of PDGFRA T674I in complex with crenolanib by soaking
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Platelet-derived growth factor receptor alpha | polymer | 356 | 40588.7 | 1 | UniProt (P16234) Pfam (PF07714) | Homo sapiens (Human) | PDGFR-alpha,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a antigen,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2,PDGFR-2 |
| 2 | B (A) | 1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine | non-polymer | 443.5 | 1 | Chemie (6T2) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F, G, H, I... (A) | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 5 | L (A) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 550 - 768 (UniProt: P16234)
A: 769 - 973 (UniProt: P16234)
| PDB | External Database | Details |
|---|---|---|
| Gly 546 | - | expression tag |
| Ala 547 | - | expression tag |
| Met 548 | - | expression tag |
| Asp 549 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40588.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 883.8 | |
| All* | Total formula weight | 41472.6 |
